{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:51:35Z","timestamp":1791445895292,"version":"4.3.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1004,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess bone status expressed as hip bone mineral density (BMD) in men with heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 141 male patients with HF underwent dual energy X-ray absorptiometry to assess their BMD. We analysed markers of bone metabolism. Patients were classified as lower versus higher BMD according to the median hip BMD (median = 1.162\u2009g\/cm2). Survival was assessed over 8\u2009years of follow-up. Patients with lower BMD were older (71\u2009\u00b1\u200910 vs. 66\u2009\u00b1\u20099\u2009years, p = 0.004), more likely to be sarcopenic (37% vs. 7%, p\u2009&amp;lt;\u20090.001) and to have lower peak oxygen consumption (absolute peak VO2 1373\u2009\u00b1\u2009480 vs. 1676\u2009\u00b1\u2009447\u2009ml\/min, p\u2009&amp;lt;\u20090.001), had higher osteoprotegerin and osteocalcin levels (both p\u2009&amp;lt;\u20090.05) compared to patients with higher BMD. Among 47 patients with repeated BMD assessments, a significant reduction in BMD was noted over 30\u2009months of follow-up. In multivariate logistic regression analysis, serum osteocalcin remained independently related with lower BMD (odds ratio [OR] 1.738, 95% confidence interval [CI] 1.136\u20132.660, p = 0.011). Hip BMD and serum osteoprotegerin were independent predictors of impaired survival on Cox proportional hazard analysis (hazard ratio [HR] 0.069, 95% CI 0.011\u20130.444, p = 0.005, and HR 0.638, 95% CI 0.472\u20130.864, p = 0.004, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with HF lose BMD over time. Markers of bone turnover can help in identifying patients at risk with osteocalcin being an independent marker of lower hip BMD and osteoprotegerin an independent predictor of death. HF patients with increased osteocalcin and osteoprotegerin may benefit from BMD assessment as manifest osteoporosis seems to be too late for clinically meaningful intervention in HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2794","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T20:24:40Z","timestamp":1676319880000},"page":"714-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bone Status in Men with Heart Failure: Results from the Studies Investigating Co-Morbidities Aggravating Heart Failure"],"prefix":"10.1093","volume":"25","author":[{"given":"Goran","family":"Loncar","sequence":"first","affiliation":[{"name":"Dedinje Cardiovascular Institute , Belgrade ,","place":["Serbia"]},{"name":"Faculty of Medicine, University of Belgrade , Belgrade ,","place":["Serbia"]},{"name":"Department of Cardiology and Pneumology, University Medical Center Goettingen, Georg- August University , Goettingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Garfias-Veitl","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center Goettingen, Georg- August University , Goettingen ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Goettingen , Goettingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Valentova","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center Goettingen, Georg- August University , Goettingen ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Goettingen , Goettingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Vatic","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center Goettingen, Georg- August University , Goettingen ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Goettingen , Goettingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitja","family":"Lainscak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, General Hospital Murska Sobota and Faculty of Medicine, University of Ljubljana , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Obradovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology\/Internal Medicine, Heart Center Leipzig-University Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Bernd","family":"Dschietzig","sequence":"additional","affiliation":[{"name":"Immundiagnostik AG , Neuruppin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health-Center for Regenerative Therapies (BCRT), Charit\u00e9- Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology (Virchow Klinikum), Charit\u00e9 University Medical Center Berlin , Berlin ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa A.","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Department of Translational Cardiology and Clinical Registries, Institute of Heart Diseases, Wroclaw Medical University , Wroclaw ,","place":["Poland"]},{"name":"Institute of Heart Diseases, University Hospital , Wroclaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health-Center for Regenerative Therapies (BCRT), Charit\u00e9- Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin , Berlin ,","place":["Germany"]},{"name":"Division of Cardiology and Metabolism - Heart Failure, Cachexia & Sarcopenia, Department of Cardiology (Virchow Klinikum), Charit\u00e9 University Medical Center Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center Goettingen, Georg- August University , Goettingen ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Goettingen , Goettingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"2026010913091255000_ejhf2794-bib-0001","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 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Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026010913091255000_ejhf2794-bib-0038","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.repc.2018.05.019","article-title":"Frailty in cardiovascular disease: screening tools","volume":"38","author":"Z\u00e3o","year":"2019","journal-title":"Rev Port Cardiol"},{"key":"2026010913091255000_ejhf2794-bib-0039","doi-asserted-by":"crossref","first-page":"37","DOI":"10.15420\/cfr.2018.37.1","article-title":"Heart failure and problems with frailty syndrome: why it is time to care about frailty syndrome in heart failure","volume":"5","author":"Uchmanowicz","year":"2019","journal-title":"Card Fail Rev"},{"key":"2026010913091255000_ejhf2794-bib-0040","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12020-009-9282-z","article-title":"Relationship between RANKL and neuroendocrine activation in elderly males with heart failure","volume":"37","author":"Loncar","year":"2010","journal-title":"Endocrine"},{"key":"2026010913091255000_ejhf2794-bib-0041","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ahj.2010.05.015","article-title":"Prognostic value of osteoprotegerin in chronic heart failure: the GISSI-HF trial","volume":"160","author":"Roysland","year":"2010","journal-title":"Am Heart J"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2794","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/25\/5\/714\/65494047\/eurjhf_25_5_714.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/25\/5\/714\/65494047\/eurjhf_25_5_714.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:11:18Z","timestamp":1767982278000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/25\/5\/714\/8341789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,7]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3,7]]},"published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.2794","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,3,7]]},"assertion":[{"value":"2022-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}