{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:34:17Z","timestamp":1784327657106,"version":"3.55.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":962,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cachexia, a common manifestation of malignant cancer, is not only associated with weight loss, but also with severe cardiac atrophy and impaired cardiac function. Here, we investigated the effects of ACM-001 (0.3 or 3\u2009mg\/kg\/day) in comparison to carvedilol (3 or 30\u2009mg\/kg\/day), metropolol (50 or 100\u2009mg\/kg\/day), nebivolol (1 or 10\u2009mg\/kg\/day) and tertatolol (0.5 or 5\u2009mg\/kg\/day) on cardiac mass and function in a rat cancer cachexia model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Young male Wistar Han rats were inoculated i.p. with 108 Yoshida hepatoma AH-130 cells and treated once daily with verum or placebo by gavage. Cardiac function (echocardiography), body weight and body composition (nuclear magnetic resonance scans) were assessed. The hearts of animals were euthanized on day 11 (placebo and 3\u2009mg\/kg\/day ACM-001) were used for signalling studies. Beta-blockers had no effect on tumour burden. ACM-001 reduced body weight loss (placebo: \u221234\u2009\u00b1\u20092.4\u2009g vs. 3\u2009mg\/kg\/day ACM-001: \u221214.8\u2009\u00b1\u20098.4\u2009g, p\u2009=\u20090.033). Lean mass wasting was attenuated (placebo: \u221216.5\u2009\u00b1\u20092.34\u2009g vs. 3\u2009mg\/kg\/day ACM-001: \u22122.4\u2009\u00b1\u20096.7\u2009g, p\u2009=\u20090.037), while fat loss was similar (p\u2009=\u20090.4) on day 11. Placebo animals lost left ventricular mass (\u2212101\u2009\u00b1\u200914\u2009mg), which was prevented only by 3\u2009mg\/kg\/day ACM-001 (7\u2009\u00b1\u200925\u2009mg, p\u2009&amp;lt;\u20090.01 vs. placebo). ACM-001 improved the ejection fraction (EF) (\u0394EF: placebo: \u221224.3\u2009\u00b1\u20092.6 vs. 3\u2009mg\/kg\/day ACM-001: 0.1\u2009\u00b1\u20092.9, p\u2009&amp;lt;\u20090.001). Cardiac output was 50% lower in the placebo group (\u221241\u2009\u00b1\u20094\u2009ml\/min) compared to baseline, while 3\u2009mg\/kg\/day ACM-001 preserved cardiac output (\u22125\u2009\u00b1\u20098 ml\/min, p\u2009&amp;lt;\u20090.01). The molecular mechanisms involved inhibition of protein degradation and activation of protein synthesis pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that 3\u2009mg\/kg\/day ACM-001 restores the anabolic\/catabolic balance in cardiac muscle leading to improved function. Moreover, not all beta-blockers have similar effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2840","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T04:33:55Z","timestamp":1680237235000},"page":"673-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Small Molecule ACM-001 Improves Cardiac Function in a Rat Model of Severe Cancer Cachexia"],"prefix":"10.1093","volume":"25","author":[{"given":"Mareike S.","family":"Poetsch","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Faculty of Medicine, Carl Gustav Carus Technische Universit\u00e4t Dresden , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Palus","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Van Linthout","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medicine Goettingen (UMG) , Goettingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Center for Stroke Research Berlin, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Pisana , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin 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