{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:22:11Z","timestamp":1791534131827,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":906,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31IC30_166855"],"award-info":[{"award-number":["31IC30_166855"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31IC30_166855"],"award-info":[{"award-number":["31IC30_166855"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In adults with congenital heart disease and systemic right ventricles, progressive right ventricular systolic dysfunction is common and is associated with adverse outcomes. Our aim was to assess the impact of the phosphodiesterase-5-inhibitor tadalafil on right ventricular systolic function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This was a double-blind, randomized, placebo-controlled, multicentre superiority trial (NCT03049540) involving 100 adults with systemic right ventricles (33 women, mean age: 40.7\u2009\u00b1\u200910.7\u2009years), comparing tadalafil 20\u2009mg once daily versus placebo (1:1 ratio). The primary endpoint was the change in right ventricular end-systolic volume after 3\u2009years of therapy. Secondary endpoints were changes in right ventricular ejection fraction, exercise capacity and N-terminal pro-B-type natriuretic peptide concentration. Primary endpoint assessment by intention to treat analysis at 3\u2009years of follow-up was possible in 83 patients (42 patients in the tadalafil group and 41 patients in the placebo group). No significant changes over time in right ventricular end-systolic volumes were observed in the tadalafil and the placebo group, and no significant differences between treatment groups (3.4\u2009ml, 95% confidence interval \u22124.3 to 11.0, p\u2009=\u20090.39). No significant changes over time were observed for the pre-specified secondary endpoints for the entire study population, without differences between the tadalafil and the placebo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this trial in adults with systemic right ventricles, right ventricular systolic function, exercise capacity and neuro-hormonal activation remained stable over a 3-year follow-up period. No significant treatment effect of tadalafil was observed. Further research is needed to find effective treatment for improvement of ventricular function in adults with systemic right ventricles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2924","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T08:40:45Z","timestamp":1685695245000},"page":"1105-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Phosphodiesterase-5 Inhibition on Systemic Right Ventricular Size and Function. A Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial: SERVE"],"prefix":"10.1093","volume":"25","author":[{"given":"Matthias","family":"Greutmann","sequence":"first","affiliation":[{"name":"University Heart Center, Department of cardiology, University of Zurich , Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tobler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital St. Gallen , St. Gallen ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik","family":"Heg","sequence":"additional","affiliation":[{"name":"CTU Bern, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Frenk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Congenital Heart Disease, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vienna General Hospital, Medical University of Vienna , Vienna 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Buechel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Children's Hospital, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Beitzke","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Haaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Wustmann","sequence":"additional","affiliation":[{"name":"Cardiac MR Center of the University Hospital Lausanne and CMR Corelab (swissCVIcorelab, CHUV) , Lausanne 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Medicine, Lausanne University (UniL) , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Bouchardy","sequence":"additional","affiliation":[{"name":"Service of Cardiology, Lausanne University Hospital and University of Lausanne , Lausanne ,","place":["Switzerland"]},{"name":"Division of Cardiology, H\u00f4pitaux Universitaires de Gen\u00e8ve (HUG) , Gen\u00e8ve ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schwerzmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Congenital Heart Disease, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]},{"name":"Division of Cardiology, University of Ottawa Heart Institute , Ottawa, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SERVE 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