{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:23:05Z","timestamp":1774981385575,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":809,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A high resting heart rate (RHR) and low systolic blood pressure (SBP) are a risk factor and a risk indicator, respectively, for poor heart failure (HF) outcomes. This analysis evaluated the associations between baseline RHR and SBP with outcomes and treatment patterns in patients with HF and reduced ejection fraction (HFrEF) in the QUALIFY (QUality of Adherence to guideline recommendations for LIFe-saving treatment in heart failure surveY) international registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Between September 2013 and December 2014, 7317 HFrEF patients with a previous HF hospitalization within 1\u201315\u2009months were enrolled in the QUALIFY registry. Complete follow-up data were available for 5138 patients. The relationships between RHR and SBP and outcomes were assessed using a Cox proportional hazards model and were analysed according to baseline values as high RHR (H-RHR) \u226575\u2009bpm versus low RHR (L-RHR) &amp;lt;75\u2009bpm and high SBP (H-SBP) \u2265110\u2009mmHg versus low SBP (L-SBP) &amp;lt;110\u2009mmHg and analysed according to each of the following four phenotypes: H-RHR\/L-SBP, L-RHR\/L-SBP, H-RHR\/H-SBP and L-RHR\/H-SBP (reference group). Compared to the reference group, H-RHR\/L-SBP was associated with the worst outcomes for the combined primary endpoint of cardiovascular death and HF hospitalization (hazard ratio [HR] 1.83, 95% confidence interval [CI] 1.51\u20132.21, p\u2009&amp;lt;\u20090.001), cardiovascular death (HR 2.70, 95% CI 1.69\u20134.33, p\u2009&amp;lt;\u20090.001), and HF hospitalization (HR 1.62, 95% CI 1.30\u20132.01, p\u2009&amp;lt;\u20090.001). Low-risk patients with L-RHR\/H-SBP achieved more frequently \u226550% of target doses of angiotensin-converting enzyme inhibitors (ACEIs) and beta-blockers (BBs) than the other groups. However, 48% and 46% of low-risk patients were not well treated with ACEIs and BBs, respectively (\u226450% of target dose or no treatment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with HFrEF and recent hospitalization, elevated RHR and lower SBP identify patients at increased risk for cardiovascular endpoints. While SBP and RHR are often recognized as barriers that deter physicians from treating with high doses of recommended drugs, they are not the only reason leaving many patients suboptimally treated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3023","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T03:55:20Z","timestamp":1693799720000},"page":"1985-1993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations Between Baseline Heart Rate and Blood Pressure and Time to Events in Heart Failure with Reduced Ejection Fraction Patients: Data from the QUALIFY International Registry"],"prefix":"10.1093","volume":"25","author":[{"given":"Amr","family":"Abdin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine, Saarland University, Saarland University Medical Center , Homburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology & Berlin Institute of Health Center for Regenerative Therapies (BCRT), German Center for Cardiovascular Research (DZHK), partner site Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin (Campus CVK) , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Cowie","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine, Faculty of Life Sciences & Medicine, King's College London (Royal Brompton Hospital) , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos S.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National and Kapodistrian University of Athens, School of Medicine, Athens University Hospital Attikon , Athens ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Center for Heart Diseases, University Hospital, Medical University , Wroclaw ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, GVM Care & Research , Cotignola ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Sch\u00f6pe","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University, Campus Homburg , Saarbr\u00fccken ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Wagenpfeil","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University, Campus Homburg , Saarbr\u00fccken ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Komajda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Saint Joseph , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine, Saarland University, Saarland University Medical Center , Homburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"2026010913113742600_ejhf3023-bib-0001","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics-2018 update: A report from the American Heart 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