{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:00:29Z","timestamp":1790784029010,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":809,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to give contemporary insight into the use of Impella and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in acute myocardial infarction-related cardiogenic shock (AMICS) and into associated outcomes, adverse events, and resource demands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This nationwide observational cohort study describes all AMICS patients treated with Impella (ABIOMED, Danvers, MA, USA) and\/or VA-ECMO in 2020\u20132021. Impella and\/or VA-ECMO were used in 20% of all AMICS cases (n\u2009=\u20094088). Impella patients were older (34% vs. 13% &amp;gt;75\u2009years, p\u2009&amp;lt;\u20090.001) and less frequently presented after an out-of-hospital cardiac arrest (18% vs. 40%, p\u2009&amp;lt;\u20090.001). In-hospital mortality was lower in the Impella versus VA-ECMO cohort (61% vs. 67%, p\u2009=\u20090.001). Adverse events occurred less frequently in Impella-supported patients: acute haemorrhagic anaemia (36% vs. 68%, p\u2009&amp;lt;\u20090.001), cerebrovascular accidents (4% vs. 11%, p\u2009&amp;lt;\u20090.001), thromboembolisms of the extremities (5% vs. 8%, p\u2009&amp;lt;\u20090.001), systemic inflammatory response syndrome (21% vs. 25%, p\u2009=\u20090.004), acute kidney injury (44% vs. 53%, p\u2009&amp;lt;\u20090.001), and acute liver failure (7% vs. 12%, p\u2009&amp;lt;\u20090.001). Impella patients were discharged home directly more often (20% vs. 11%, p\u2009&amp;lt;\u20090.001) whereas VA-ECMO patients were more often discharged to another care facility (22% vs. 19%, p\u2009=\u20090.031). Impella patients had shorter hospital stays and lower hospital costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the largest, most recent European cohort study describing outcomes, adverse events, and resource demands based on claims data in patients with Impella and\/or VA-ECMO. Overall, adverse event rates and resource consumption were high. Given the current lack of beneficial evidence, our study reinforces the need for prospectively established, high-quality evidence to guide clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3025","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T05:11:40Z","timestamp":1693977100000},"page":"2021-2031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Impella and Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock Complicating Acute Myocardial Infarction"],"prefix":"10.1093","volume":"25","author":[{"given":"Margriet","family":"Bogerd","sequence":"first","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam Cardiovascular Sciences , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"ten 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