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Trust","doi-asserted-by":"publisher","award":["21JTA"],"award-info":[{"award-number":["21JTA"]}],"id":[{"id":"10.13039\/501100000282","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the relevance of genetic and cardiovascular magnetic resonance (CMR) features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This study includes two cohorts. First, individuals with CAD recruited into the UK Biobank (UKB) were evaluated. Second, patients with CAD referred to a tertiary centre for evaluation with late gadolinium enhancement (LGE)-CMR were recruited (London cohort); patients underwent genetic sequencing as part of the research protocol and long-term follow-up. From 31\u2009154 individuals with CAD recruited to UKB, rare pathogenic variants in DCM genes were associated with increased risk of death or major adverse cardiac events (hazard ratio 1.57, 95% confidence interval [CI] 1.22\u20132.01, p\u2009&amp;lt;\u20090.001). Of 1619 individuals with CAD included from the UKB CMR substudy, participants with a rare variant in a DCM-associated gene had lower left ventricular ejection fraction (LVEF) compared to genotype negative individuals (mean 47\u2009\u00b1\u200910% vs. 57\u2009\u00b1\u20098%, p\u2009&amp;lt;\u20090.001). Of 453 patients in the London cohort, 63 (14%) had non-infarct pattern LGE (NI-LGE) on CMR. Patients with NI-LGE had lower LVEF (mean 38\u2009\u00b1\u200918% vs. 48\u2009\u00b1\u200916%, p\u2009&amp;lt;\u20090.001) compared to patients without NI-LGE, with no significant difference in the burden of rare protein altering variants in DCM-associated genes between groups (9.5% vs. 6.7%, odds ratio 1.5, 95% CI 0.4\u20134.3, p\u2009=\u20090.4). NI-LGE was not independently associated with adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rare pathogenic variants in DCM-associated genes impact left ventricular remodelling and outcomes in stable CAD. NI-LGE is associated with adverse remodelling but is not an independent predictor of outcome and had no rare genetic basis in our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3033","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T06:56:00Z","timestamp":1694588160000},"page":"46-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessing the Association Between Genetic and Phenotypic Features of Dilated Cardiomyopathy and Outcome in Patients with Coronary Artery Disease"],"prefix":"10.1093","volume":"26","author":[{"given":"Richard E.","family":"Jones","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , London ,","place":["UK"]},{"name":"Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust , London ,","place":["UK"]},{"name":"Anglia Ruskin University , Chelmsford ,","place":["UK"]},{"name":"Essex Cardiothoracic Centre , Basildon ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Hammersley","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , London ,","place":["UK"]},{"name":"Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , London ,","place":["UK"]},{"name":"MRC London Institute of Medical Sciences, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"McGurk","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , London ,","place":["UK"]},{"name":"MRC 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