{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:19:04Z","timestamp":1790313544668,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":718,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transthyretin cardiac amyloidosis (ATTR-CA) is an infiltrative cardiomyopathy that commonly presents with concomitant chronic kidney disease. Albuminuria is common in heart failure and associated with worse outcomes, but its prevalence and relationship to outcome in ATTR-CA remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 1181 patients with ATTR-CA were studied (mean age 78.1\u2009\u00b1\u20097.9\u2009years; 1022 [86.5%] male; median estimated glomerular filtration rate 59\u2009ml\/min\/1.73m2 [interquartile range: 47\u201374]). Albuminuria was present in 563 (47.7%) patients (499 [88.6%] with microalbuminuria and 64 [11.4%] with macroalbuminuria). Patients with albuminuria had a more severe cardiac phenotype evidenced by higher serum cardiac biomarkers (median N-terminal pro-B-type natriuretic peptide [NT-proBNP]: 4027\u2009ng\/L [2173\u20136889] vs. 1851\u2009ng\/L [997\u20133209], p\u2009&amp;lt;\u20090.001; median troponin T: 69\u2009ng\/L [46\u2013101] vs. 48\u2009ng\/L [34\u201368], p\u2009&amp;lt;\u20090.001) and worse echocardiographic indices of systolic (longitudinal strain: \u221210.0\u2009\u00b1\u20093.6% vs. \u221211.6\u2009\u00b1\u20093.8%, p\u2009&amp;lt;\u20090.001) and diastolic function (E\/e\u2032: 17.5\u2009\u00b1\u20096.4 vs. 16.4\u2009\u00b1\u20096.7, p\u2009&amp;lt;\u20090.001) than those with a normal urinary albumin to creatinine ratio (UACR). Microalbuminuria and macroalbuminuria were independently associated with mortality in the overall population (hazard ratio [HR] 1.47, 95% confidence interval [CI] 1.13\u20131.92, p\u2009=\u20090.005 and HR 1.87, 95% CI 1.15\u20133.05, p\u2009=\u20090.012, respectively). In a subgroup of patients (n\u2009=\u2009349) without concomitant hypertension, diabetes mellitus or chronic kidney disease, albuminuria was also associated with mortality (HR 2.98, 95% CI 1.72\u20135.17, p\u2009&amp;lt;\u20090.001). At 12\u2009months, 330 patients had a repeat UACR measurement; those in whom UACR increased by 30% or more (n\u2009=\u2009148, 44.8%) had an increased risk of mortality (HR 1.84, 95% CI 1.06\u20133.19, p\u2009=\u20090.030).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Albuminuria is common in patients with ATTR-CA, and more prevalent in those with a more severe cardiac phenotype. Albuminuria at diagnosis and a significant increase in UACR during follow-up are associated with mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3094","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T19:57:34Z","timestamp":1700855854000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Albuminuria in Transthyretin Cardiac Amyloidosis: Prevalence, Progression and Prognostic Importance"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5017-8657","authenticated-orcid":false,"given":"Adam","family":"Ioannou","sequence":"first","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad U.","family":"Rauf","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi K.","family":"Patel","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuf","family":"Razvi","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldostefano","family":"Porcari","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]},{"name":"Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Martinez-Naharro","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Venneri","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bandera","sequence":"additional","affiliation":[{"name":"Cardiology University Department, IRCCS Policlinico San Donato , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Virsinskaite","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Kotecha","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Knight","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Petrie","sequence":"additional","affiliation":[{"name":"University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Whelan","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Wechalekar","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lachmann","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London, Royal Free Campus , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School , Boston, MA 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