{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:19:10Z","timestamp":1788542350099,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 160761"],"award-info":[{"award-number":["R01 160761"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL158517"],"award-info":[{"award-number":["R01 HL158517"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23 HL141448"],"award-info":[{"award-number":["K23 HL141448"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 160761"],"award-info":[{"award-number":["R01 160761"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL158517"],"award-info":[{"award-number":["R01 HL158517"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23 HL141448"],"award-info":[{"award-number":["K23 HL141448"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The normal (i.e. expected) haemodynamics in adults post-Fontan remain poorly delineated. Moreover, the definitions of elevated exercise pulmonary artery (PA) and PA wedge pressure (PAWP) for this population have not been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Seventy-two adults post-Fontan undergoing exercise catheterization were categorized into abnormal (Group I, n\u2009=\u200959; defined as resting mean PA \u226514\u2009mmHg and\/or PAWP \u226512\u2009mmHg, \u0394PAWP\/\u0394systemic flow [Qs] &amp;gt;2\u2009mmHg\/L\/min, and\/or \u0394PA\/\u0394pulmonary flow &amp;gt;3\u2009mmHg\/L\/min) and normal (Group II, n\u2009=\u200913) haemodynamics. Thirty-nine patients with non-cardiac dyspnoea (NCD) were included as controls. There was no difference in exercise arterial oxygen saturation (87% [81\u201392] vs. 89% [85\u201393], p\u2009=\u20090.29), while exercise PA pressure (27 [23\u201331] vs. 16 [14.5\u201319.5] mmHg, p\u2009&amp;lt;\u20090.001) and PAWP were higher (21 [18\u201328] vs. 12 [8\u201314] mmHg, p\u2009&amp;lt;\u20090.001) in Group I. At peak exercise, Group I had lower heart rate (97 [81\u2013120] vs. 133 [112.5\u2013147.5] bpm, p\u2009&amp;lt;\u20090.001) and Qs response (67.3 [43.8\u201393.1] vs. 105.9 (82\u2013118.5)\u2009% predicted, p\u2009&amp;lt;\u20090.001) than Group II. Exercise superior vena cava pressures were higher (16 [14\u201322.5] vs. 5.5 [3\u20137.3] mmHg, p\u2009&amp;lt;\u20090.001) and arterial oxygen saturation lower (89% [85\u201393] vs. 97% [96\u201398], p\u2009&amp;lt;\u20090.001) in Group II compared to NCD, while no differences in PAWP, stroke volume index, heart rate, or Qs response were seen. If defined as two standard deviations above mean values for Group II, elevated PAWP and mean PA pressure post-Fontan would correspond to 20.6\u2009mmHg and 25.8\u2009mmHg, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PAWP &amp;gt;20\u2009mmHg and mean PA pressure &amp;gt;25\u2009mmHg could be used to define elevated values during exercise in adults post-Fontan. The major discrepancy in exercise haemodynamics among Group II compared to controls appears to be the degree of systemic venous hypertension and arterial desaturation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3119","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T02:20:23Z","timestamp":1703816423000},"page":"314-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Exercise Catheterization in Adults Post-Fontan with Normal and Abnormal Haemodynamic Criteria: Insights Into Normal Fontan Physiology"],"prefix":"10.1093","volume":"26","author":[{"given":"William R.","family":"Miranda","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Charles","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J.","family":"Burchill","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Van De Bruaene","sequence":"additional","affiliation":[{"name":"Division 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