{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:00:50Z","timestamp":1791525650601,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":613,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Else-Kroener-Fresenius-Foundation, Bad Homburg, Germany"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While invasively determined congestion holds mechanistic and prognostic significance in acute heart failure (HF), its role in patients with tricuspid regurgitation (TR)-related right- heart failure (HF) undergoing transcatheter tricuspid valve intervention (TTVI) is less well established. A comprehensive understanding of congestion patterns might aid in procedural planning, risk stratification, and the identification of patients who may benefit from adjunctive therapies before undergoing TTVI. The aim of this study was to investigate the role of congestion patterns in patients with severe TR and its implications for TTVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Within a multicentre, international TTVI registry, 813 patients underwent right heart catheterization (RHC) prior to TTVI and were followed up to 24\u2009months. The median age was 80 (interquartile range 76\u201383) years and 54% were women. Both mean right atrial pressure (RAP) and pulmonary capillary wedge pressure (PCWP) were associated with 2-year mortality on Cox regression analyses with Youden index-derived cut-offs of 17\u2009mmHg and 19\u2009mmHg, respectively (p\u2009&amp;lt;\u20090.01 for all). However, RAP emerged as an independent predictor of outcomes following multivariable adjustments. Pre-interventionally, 42% of patients were classified as euvolaemic (RAP &amp;lt;17\u2009mmHg, PCWP &amp;lt;19\u2009mmHg), 23% as having left-sided congestion (RAP &amp;lt;17\u2009mmHg, PCWP \u226519\u2009mmHg), 8% as right-sided congestion (RAP \u226517\u2009mmHg, PCWP &amp;lt;19\u2009mmHg), and 27% as bilateral congestion (RAP \u226517\u2009mmHg, PCWP \u226519\u2009mmHg). Patients with right-sided or bilateral congestion had the lowest procedural success rates and shortest survival times. Congestion patterns allowed for discerning specific patient's physiology and specifying prognostic implications of right ventricular to pulmonary artery coupling surrogates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large cohort of invasively characterized patients undergoing TTVI, congestion patterns involving right-sided congestion were associated with low procedural success and higher mortality rates after TTVI. Whether pre-interventional reduction of right-sided congestion can improve outcomes after TTVI should be established in dedicated studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3235","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T03:30:35Z","timestamp":1712201435000},"page":"1004-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Congestion Patterns in Severe Tricuspid Regurgitation and Transcatheter Treatment: Insights from a Multicentre Registry"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-8138","authenticated-orcid":false,"given":"Karl-Philipp","family":"Rommel","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart Center at University of Leipzig and Leipzig Heart Institute , Leipzig ,","place":["Germany"]},{"name":"Cardiovacular Research Foundation , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Cardiovacular Research Foundation , New York, NY ,","place":["USA"]},{"name":"University of Bordeaux, Hopital Cardiologique Haut-L\u00e9v\u00eaque, University Hospital , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Fortmeier","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Stolz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig Maximilians University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne R.","family":"Sch\u00f6ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center at University of Leipzig and Leipzig Heart Institute , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"von Stein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kassar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital Bern, Bern University Hospital , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Ger\u00e7ek","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology, Heart and Diabetes 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