{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:19:32Z","timestamp":1785568772860,"version":"3.56.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":581,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2017-21"],"award-info":[{"award-number":["2017-21"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2017-11"],"award-info":[{"award-number":["2017-11"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2018-30"],"award-info":[{"award-number":["2018-30"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2020B005"],"award-info":[{"award-number":["2020B005"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","award":["E.013"],"award-info":[{"award-number":["E.013"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC CoG 818715"],"award-info":[{"award-number":["ERC CoG 818715"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2017\u201021"],"award-info":[{"award-number":["2017\u201021"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2017\u201011"],"award-info":[{"award-number":["2017\u201011"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2018\u201030"],"award-info":[{"award-number":["2018\u201030"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2020B005"],"award-info":[{"award-number":["2020B005"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","award":["E.013"],"award-info":[{"award-number":["E.013"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC CoG 818715"],"award-info":[{"award-number":["ERC CoG 818715"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Senescence is a major risk factor for heart failure (HF), and insulin-like growth factor-binding protein-7 (IGFBP7) has been identified as an important senescence-inducing factor. The aim of this study was to examine the value of baseline and repeat IGFBP7 measurements in predicting future HF among community-dwelling Dutch adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Individuals without prevalent HF who attended PREVEND visits 2 and 4 median of 5.1\u2009years apart (25th\u201375th percentile, 4.9\u20135.2) with measurements of IGFBP7 were included. We used Cox proportional hazards models to investigate the association between IGFBP7 and HF incidence. A total of 6125 participants attending visit 2 (mean\u2009\u00b1\u2009standard deviation [SD] age 53.1\u2009\u00b1\u200912.2\u2009years; 3151 [51.4%] men) were followed for a median of 8.4 (7.8\u20138.9)\u2009years, and 194 participants (3.2%) developed incident HF. Median baseline IGFBP7 concentration was 87.0 (75.1\u201397.3)\u2009ng\/ml, and baseline IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted hazard ratio [HR] per 1 SD change in log-transformed IGFBP7: 1.22, 95% confidence interval [CI] 1.03\u20131.46). Baseline IGFBP7 was also significantly associated with incident HF in individuals with N-terminal pro-B-type natriuretic peptide &amp;lt;125\u2009ng\/L. Among 3879 participants attending both visits 2 and 4 (mean\u2009\u00b1\u2009SD age 57.5\u2009\u00b1\u200911.3\u2009years; 1952 [50.3%] men), 93 individuals developed HF (after visit 4) during a median follow-up of 3.2 (2.8\u20133.9) years. Median increase in IGFBP7 concentration between visits was 0.68 (\u22127.09 to 8.36)\u2009ng\/ml, and changes in IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted HR per 1 SD change in log-transformed IGFBP7: 1.68, 95% CI 1.19\u20132.36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both baseline as well as repeat IGFBP7 measurements provide information about the risk of developing HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3328","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:09:32Z","timestamp":1721189372000},"page":"1755-1763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of Baseline and Longitudinal Changes in Insulin-Like Growth Factor-Binding Protein-7 with the Risk of Incident Heart Failure: Data from the PREVEND Study"],"prefix":"10.1093","volume":"27","author":[{"given":"Sabrina","family":"Abou Kamar","sequence":"first","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC , Rotterdam ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Franciscus Gasthuis & Vlietland , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bracun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maissa","family":"El-Qendouci","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Bomer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J.L.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T.","family":"Gansevoort","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Kardys","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-9140","authenticated-orcid":false,"given":"Rudolf A.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-2897","authenticated-orcid":false,"given":"Navin","family":"Suthahar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"2026021721453560800_ejhf3328-bib-0001","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/CIRCRESAHA.121.318172","article-title":"Epidemiology of heart failure: A contemporary perspective","volume":"128","author":"Roger","year":"2021","journal-title":"Circ Res"},{"key":"2026021721453560800_ejhf3328-bib-0002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0003","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1161\/CIRCULATIONAHA.111.070235","article-title":"Advances in the epidemiology of heart failure and left ventricular remodeling","volume":"124","author":"Cheng","year":"2011","journal-title":"Circulation"},{"key":"2026021721453560800_ejhf3328-bib-0004","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ejhf.3048","article-title":"The different risk of new-onset, chronic, worsening, and advanced heart failure: A systematic review and meta-regression analysis","volume":"26","author":"Shakoor","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0005","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nrm.2017.68","article-title":"Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases","volume":"18","author":"Kubben","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026021721453560800_ejhf3328-bib-0006","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/cvr\/cvab161","article-title":"Senescence mechanisms and targets in the heart","volume":"118","author":"Chen","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2026021721453560800_ejhf3328-bib-0007","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jjcc.2019.05.002","article-title":"Cellular senescence in cardiac diseases","volume":"74","author":"Shimizu","year":"2019","journal-title":"J Cardiol"},{"key":"2026021721453560800_ejhf3328-bib-0008","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/s44161-022-00181-y","article-title":"Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure","volume":"1","author":"Zhang","year":"2022","journal-title":"Nat Cardiovasc Res."},{"key":"2026021721453560800_ejhf3328-bib-0009","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005133","article-title":"IGFBP7 (insulin-like growth factor-binding protein-7) and neprilysin inhibition in patients with heart failure","volume":"11","author":"Januzzi","year":"2018","journal-title":"Circ Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0010","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1002\/ehf2.14120","article-title":"Insulin-like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence","volume":"9","author":"Bracun","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0011","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jchf.2022.09.004","article-title":"IGFBP-7 and outcomes in heart failure with reduced ejection fraction: Findings from DAPA-HF","volume":"11","author":"Adamson","year":"2023","journal-title":"JACC Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0012","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1053\/j.ajkd.2012.06.017","article-title":"Albuminuria, estimated GFR, traditional risk factors, and incident cardiovascular disease: The PREVEND (Prevention of Renal and Vascular Endstage Disease) study","volume":"60","author":"Smink","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"2026021721453560800_ejhf3328-bib-0013","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1161\/01.CIR.0000031732.78052.81","article-title":"Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population","volume":"106","author":"Hillege","year":"2002","journal-title":"Circulation"},{"key":"2026021721453560800_ejhf3328-bib-0014","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41598-021-02409-6","article-title":"Relative fat mass, a new index of adiposity, is strongly associated with incident heart failure: Data from PREVEND","volume":"12","author":"Suthahar","year":"2022","journal-title":"Sci Rep"},{"key":"2026021721453560800_ejhf3328-bib-0015","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/eurheartj\/eht066","article-title":"Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND","volume":"34","author":"Brouwers","year":"2013","journal-title":"Eur Heart J"},{"key":"2026021721453560800_ejhf3328-bib-0016","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"2026021721453560800_ejhf3328-bib-0017","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/CIRCHEARTFAILURE.114.001185","article-title":"Clinical risk stratification optimizes value of biomarkers to predict new-onset heart failure in a community-based cohort","volume":"7","author":"Brouwers","year":"2014","journal-title":"Circ Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0018","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12265-013-9522-8","article-title":"Measurement of novel biomarkers to predict chronic heart failure outcomes and left ventricular remodeling","volume":"7","author":"Motiwala","year":"2014","journal-title":"J Cardiovasc Transl Res"},{"key":"2026021721453560800_ejhf3328-bib-0019","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.amjcard.2018.02.041","article-title":"Comparison of prognostic usefulness of serum insulin-like growth factor-binding protein 7 in patients with heart failure and preserved versus reduced left ventricular ejection fraction","volume":"121","author":"Hage","year":"2018","journal-title":"Am J Cardiol"},{"key":"2026021721453560800_ejhf3328-bib-0020","doi-asserted-by":"crossref","DOI":"10.3390\/biom12020274","article-title":"IGFBP7 concentration may reflect subclinical myocardial damage and kidney function in patients with stable ischemic heart disease","volume":"12","author":"Lisowska","year":"2022","journal-title":"Biomolecules"},{"key":"2026021721453560800_ejhf3328-bib-0021","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jchf.2016.08.002","article-title":"Insulin-like growth factor-binding protein-7 as a biomarker of diastolic dysfunction and functional capacity in heart failure with preserved ejection fraction: Results from the RELAX trial","volume":"4","author":"Gandhi","year":"2016","journal-title":"JACC Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0022","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12872-021-02138-8","article-title":"IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study","volume":"21","author":"Meessen","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"2026021721453560800_ejhf3328-bib-0023","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2026021721453560800_ejhf3328-bib-0024","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ahj.2005.10.011","article-title":"How obesity affects the cut-points for B-type natriuretic peptide in the diagnosis of acute heart failure. Results from the Breathing Not Properly multinational study","volume":"151","author":"Daniels","year":"2006","journal-title":"Am Heart J"},{"key":"2026021721453560800_ejhf3328-bib-0025","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/ejhf.1209","article-title":"Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population","volume":"20","author":"Suthahar","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0026","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/ejhf.1771","article-title":"Sex-related differences in contemporary biomarkers for heart failure: A review","volume":"22","author":"Suthahar","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"2026021721453560800_ejhf3328-bib-0027","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.00727","article-title":"Insulin growth factor binding protein 7 (IGFBP7)-related cancer and IGFBP3 and IGFBP7 crosstalk","volume":"10","author":"Jin","year":"2020","journal-title":"Front Oncol"},{"key":"2026021721453560800_ejhf3328-bib-0028","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"2026021721453560800_ejhf3328-bib-0029","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2009.01.045","article-title":"Insulin-like growth factor binding protein-7 (IGFBP7) blocks vascular endothelial cell growth factor (VEGF)-induced angiogenesis in human vascular endothelial cells","volume":"610","author":"Tamura","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"2026021721453560800_ejhf3328-bib-0030","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1021\/pr300010r","article-title":"Proteomic screen identifies IGFBP7 as a novel component of endothelial cell-specific Weibel-Palade bodies","volume":"11","author":"Breevoort","year":"2012","journal-title":"J Proteome Res"},{"key":"2026021721453560800_ejhf3328-bib-0031","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s44161-022-00189-4","article-title":"IGFBP7 on the road to heart failure: Driver or passenger?","volume":"1","author":"Riquelme","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"2026021721453560800_ejhf3328-bib-0032","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12990","article-title":"Forkhead box O3 protects the heart against paraquat-induced aging-associated phenotypes by upregulating the expression of antioxidant enzymes","volume":"18","author":"Chang","year":"2019","journal-title":"Aging Cell"},{"key":"2026021721453560800_ejhf3328-bib-0033","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13184","article-title":"FOXO3a acts to suppress DNA double-strand break-induced mutations","volume":"19","author":"White","year":"2020","journal-title":"Aging Cell"},{"key":"2026021721453560800_ejhf3328-bib-0034","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/jamacardio.2017.4987","article-title":"Association of cardiovascular biomarkers with incident heart failure with preserved and reduced ejection fraction","volume":"3","author":"Boer","year":"2018","journal-title":"JAMA Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/27\/9\/1755\/66834360\/eurjhf_27_9_1755.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/27\/9\/1755\/66834360\/eurjhf_27_9_1755.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:45:46Z","timestamp":1771382746000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/27\/9\/1755\/8468052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,7,17]]},"published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.3328","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"2024-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}