{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:21:24Z","timestamp":1791883284504,"version":"4.3.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7\u2010242209\u2010BIOSTAT\u2010CHF; EudraCT 2010\u2010020808\u201029"],"award-info":[{"award-number":["FP7\u2010242209\u2010BIOSTAT\u2010CHF; EudraCT 2010\u2010020808\u201029"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated the prevalence, clinical characteristics, and prognosis of patients with heart failure (HF) with improved ejection fraction (HFimpEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We used data from BIOSTAT\u2010CHF including patients with a left ventricular ejection fraction (LVEF) \u226440% at baseline who had LVEF re\u2010assessed at 9\u2009months. HFimpEF was defined as a LVEF &gt;40% and a LVEF \u226510% increase from baseline at 9\u2009months. We validated findings in the ASIAN\u2010HF registry. The primary outcome was a composite of time to HF rehospitalization or all\u2010cause mortality. In BIOSTAT\u2010CHF, about 20% of patients developed HFimpEF, that was associated with a lower primary event rate of all\u2010cause mortality (hazard ratio [HR] 0.52, 95% confidence interval [CI] 0.28\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040) and the composite endpoint (HR 0.46, 95% CI 0.30\u20130.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with patients who remained in persistent HF with reduced ejection fraction (HFrEF). The findings were similar in the ASIAN\u2010HF (HR 0.40, 95% CI 0.18\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024, and HR 0.29, 95% CI 0.17\u20130.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Five independently common predictors for HFimpEF in both BIOSTAT\u2010CHF and ASIAN\u2010HF were female sex, absence of ischaemic heart disease, higher LVEF, smaller left ventricular end\u2010diastolic and end\u2010systolic diameter at baseline. A predictive model combining only five predictors (absence of ischaemic heart disease and left bundle branch block, smaller left ventricular end\u2010systolic and left atrial diameter, and higher platelet count) for HFimpEF in the BIOSTAT\u2010CHF achieved an area under the curve of 0.772 and 0.688 in the ASIAN\u2010HF (due to missing left atrial diameter and platelet count).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately 20\u201330% of patients with HFrEF improved to HFimpEF within 1\u2009year with better clinical outcomes. In addition, the predictive model with clinical predictors could more accurately predict HFimpEF in patients with HFrEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3378","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T07:28:32Z","timestamp":1723188512000},"page":"2518-2528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Heart failure with improved versus persistently reduced left ventricular ejection fraction: A comparison of the BIOSTAT\u2010CHF (European) study with the ASIAN\u2010HF registry"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-0836","authenticated-orcid":false,"given":"Thong Huy","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, College of Life Sciences University of Leicester  Leicester UK"},{"name":"National Institute for Health and Care Research Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust, Glenfield Hospital  Leicester UK"},{"name":"Leicester van Geest Multi\u2010OMICS facility University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Ting","family":"Tay","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore and Duke\u2013National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, College of Life Sciences University of Leicester  Leicester UK"},{"name":"Leicester van Geest Multi\u2010OMICS facility University of Leicester  Leicester UK"},{"name":"Leicester Cancer Research Centre, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Health, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Tromp","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore and Duke\u2013National University of Singapore  Singapore Singapore"},{"name":"Saw Swee Hock School of Public Health National University of Singapore and the National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-956X","authenticated-orcid":false,"given":"Johanna Elisabeth","family":"Emmens","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiew\u2010Hwa Katherine","family":"Teng","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore and Duke\u2013National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchal","family":"Chandramouli","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore and Duke\u2013National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver Charles","family":"Slingsby","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, College of Life Sciences University of Leicester  Leicester UK"},{"name":"National Institute for Health and Care Research Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust, Glenfield Hospital  Leicester UK"},{"name":"Leicester van Geest Multi\u2010OMICS facility University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology (CVK), and Berlin\u2010Brandenburg Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK) Partner Site Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[{"name":"University of Bergen Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure Unit, Athens University Hospital Attikon, School of Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chim C.","family":"Lang","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University and Cardiology Department, Military Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh J.","family":"Samani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, College of Life Sciences University of Leicester  Leicester UK"},{"name":"National Institute for Health and Care Research Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust, Glenfield Hospital  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"Van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"Inserm CIC 1433 Universit\u00e9 de Lorrain  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-4963","authenticated-orcid":false,"given":"Inder S.","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota Medical School and VA Medical Center  Minneapolis MN 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