{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:08:57Z","timestamp":1794024537232,"version":"4.8.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00689"],"award-info":[{"award-number":["PI20\/00689"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00689"],"award-info":[{"award-number":["PI20\/00689"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Combination of hypertonic saline solution (HSS) with intravenous loop diuretics has been suggested to improve diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this approach in the ambulatory setting remain unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this multicentre, double-blind, randomized study, we allocated ambulatory patients with worsening heart failure (WHF) to a 1-h infusion of intravenous furosemide (ivFurosemide)-HSS versus ivFurosemide. The primary endpoint was the volume of diuresis at 3\u2009h. Secondary endpoints included 3-h natriuresis and weight variation, 7-day congestion data, kidney function and electrolytes, and 30-day clinical events. Overall, 167 participants (median age: 81\u2009years, 30.5% female) were randomized across 13 sites between December 2020 and March 2023. There were no differences in 3-h diuresis between treatments (ivFurosemide-HSS: 1099\u2009ml vs. ivFurosemide: 1103\u2009ml, p\u2009=\u20090.963), 3-h natriuresis (\u2206 +2.642\u2009mEq\/L, p\u2009=\u20090.559), or 3-h weight (\u2206 +0.012\u2009kg, p\u2009=\u20090.920). Patients in the ivFurosemide-HSS arm experienced significant weight decrease at 7\u2009days (\u0394 \u22120.586\u2009kg, p\u2009=\u20090.048). There were no between-treatment differences in clinical congestion score, biomarkers, inferior vena cava diameter, or the presence of lung ultrasound B-lines. At 30\u2009days, 26.5% of the patients in the ivFurosemide-HSS group versus 33.3% in the ivFurosemide group experienced WHF (hazard ratio 0.76, p\u2009=\u20090.330). The incidence of death from any cause or HF hospitalization was 6% of patients in the ivFurosemide-HSS group and 8.3% of patients in the ivFurosemide group (hazard ratio 0.69, p\u2009=\u20090.521). The incidence of worsening kidney function or metabolic derangements was not significantly different in the two arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single infusion of ivFurosemide-HSS did not improve 3-h diuresis or congestion parameters in patients with ambulatory WHF. This therapy showed an appropriate safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3390","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T07:24:59Z","timestamp":1721978699000},"page":"2118-2128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy and Safety of Hypertonic Saline Therapy in Ambulatory Patients with Heart Failure: The SALT-HF Trial"],"prefix":"10.1093","volume":"26","author":[{"given":"Marta","family":"Cobo Marcos","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro , Madrid ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER Cardiovascular) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario de Valencia (INCLIVA), University of Valencia , Valencia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Com\u00edn-Colet","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER Cardiovascular) , Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital Universitario de Bellvitge, IDIBELL , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Zegr\u00ed-Reiriz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital de la Santa Creu i Sant Pau , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Rubio Gracia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Lozano Blesa, University of Zaragoza, Aragon Health Research Institute (IIS Aragon) , Zaragoza ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Morales-Rull","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Arnau de Vilanova. Heart Failure Unit, Lleida Health Region. Institut de Recerca Biom\u00e8dica de Lleida (IRBLleida) , Lleida ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Ll\u00e0cer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS , Madrid ,","place":["Spain"]},{"name":"Department of Medicine and Medical Specialties, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcal\u00e1 , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"D\u00edez-Villanueva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario de la Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Jim\u00e9nez-Marrero","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER Cardiovascular) , Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital Universitario de Bellvitge, IDIBELL , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"de Juan Bagud\u00e1","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER Cardiovascular) , Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, University Hospital 12 de Octubre, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12) , Madrid ,","place":["Spain"]},{"name":"Department of Medicine, Faculty of Biomedical and Health Science, Universidad Europea de Madrid , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ortiz Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario San Pedro de Alc\u00e1ntara , C\u00e1ceres ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alejandra","family":"Restrepo-C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Cl\u00ednico San Carlos , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josebe","family":"Goirigolzarri-Artaza","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Cl\u00ednico San Carlos , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Manuel","family":"Garc\u00eda-Pinilla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Virgen de la Victoria, M\u00e1laga, Spain, Instituto de Investigaci\u00f3n Biom\u00e9dica-Plataforma BIONAND, M\u00e1laga Ciber-Cardiovascular, Insitituto de Salud Carlos III, Departamento de Medicina y Dermatolog\u00eda, Universidad de M\u00e1laga , M\u00e1laga ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Barrios","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Rey Juan Carlos M\u00f3stoles , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"del Prado D\u00edaz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER Cardiovascular) , Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital Universitario Ram\u00f3n y Cajal , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Montero Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Puerta de Hierro Majadahonda , Madrid 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