{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:41:45Z","timestamp":1791315705738,"version":"4.3.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":493,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Evidence on the relative impact of diverse genetic backgrounds associated with non-ischaemic dilated cardiomyopathy (DCM) remains contradictory. This study sought to synthesize the available data regarding long-term outcomes of different gene groups in DCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Electronic databases were systematically screened to identify studies reporting prognostic data on pre-specified gene groups. Those included pathogenic\/likely pathogenic (P\/LP) variants, truncating titin variants (TTNtv), lamin A\/C variants (LMNA), and desmosomal proteins. Outcomes were divided into composite adverse events (CAEs), malignant ventricular arrhythmic events (MVAEs) and heart failure events (HFEs). A total of 26 studies (n\u2009=\u20097255) were included in the meta-analysis and 6791 patients with genotyped DCM were analysed. Patients with P\/LP variants had a higher risk for CAEs (odds ratio [OR] 2.10, 95% confidence interval [CI] 1.67\u20132.65), MVAEs (OR 1.86, 95% CI 1.52\u20132.26), and HFEs (OR 2.01, 95% CI 1.08\u20133.73) than genotype-negative patients. The presence of TTNtv was linked to a higher risk for CAEs (OR 1.78, 95% CI 1.20\u20132.63), but not MVAEs or HFEs. LMNA and desmosomal groups suffered a higher risk for CAEs, MVAEs, and HFEs compared to non-LMNA and non-desmosomal groups, respectively. When genes were indirectly compared, the presence of LMNA resulted in a more detrimental effect that TTNtv, with respect to all composite outcomes but no significant difference was found between LMNA and desmosomal genes. Desmosomal genes harboured a higher risk for MVAEs compared to TTNtv.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Different genetic substrates associated with DCM result in divergent natural histories. Routine utilization of genetic testing should be employed to refine risk stratification and inform therapeutic strategies in DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3403","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T11:24:28Z","timestamp":1722338668000},"page":"2155-2168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prognostic Implications of Genotype Findings in Non-Ischaemic Dilated Cardiomyopathy: A Network Meta-Analysis"],"prefix":"10.1093","volume":"26","author":[{"given":"Vasileios","family":"Anastasiou","sequence":"first","affiliation":[{"name":"1st Department of Cardiology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki , Thessaloniki ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas 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School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki , Thessaloniki ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiris","family":"Katranas","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki , Thessaloniki ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Rouskas","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki , Thessaloniki ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthaios","family":"Didagelos","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki , Thessaloniki 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