{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:08:33Z","timestamp":1774897713266,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00393"],"award-info":[{"award-number":["PI18\/00393"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate whether seasonal influenza and COVID-19 vaccinations influence the severity of decompensations and long-term outcomes of patients with acute heart failure (AHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We included consecutive AHF patients attended at 40 Spanish emergency departments during November and December 2022. They were grouped according to whether they had received seasonal influenza and COVID-19 vaccination. The severity of heart failure (HF) decompensation was assessed with the MEESSI scale, need for hospitalization, intensive care unit (ICU) admission, and in-hospital mortality. Long-term outcomes were 90-day and 1-year all-cause mortality. Associations between vaccination, HF decompensation severity, and long-term outcomes were investigated. Subgroup analyses were executed for 16 patient characteristics and their relationship with vaccination and 1-year mortality. We analysed 4243 patients (median age 85\u2009years; interquartile range 77\u201390; 57% female): 1841 (43%) had received influenza vaccination, 3139 (74%) COVID-19 vaccination, 1773 (41.8%) received both vaccines (full vaccination) and 1036 (24.4%) none. Previous episodes of AHF, chronic obstructive pulmonary disease and chronic treatment with diuretics were associated with vaccination (either influenza, COVID-19 and full vaccination). High or very-high risk decompensation occurred in 18.6%; hospitalization in 72.3%, ICU admission in 1.1%, and in-hospital mortality in 8.4%. Influenza vaccination was associated with lower hospitalization rates (adjusted odds ratio [OR] 0.746, 95% confidence interval [CI] 0.636\u20130.876) and in-hospital mortality (OR 0.761, 95% CI 0.583\u20130.992), while COVID-19 vaccination was associated with increased hospitalizations (OR 1.215, 95% CI 1.016\u20131.454). Overall, 90-day and 1-year mortality were 20.3% and 34.4%. Both were decreased in influenza-vaccinated patients (adjusted hazard ratio [HR] 0.831, 95% CI 0.709\u20130.973; and HR 0.885, 95% CI 0.785\u20130.999, respectively) but only at 90\u2009days in COVID-19 vaccinated patients (HR 0.829, 95% CI 0.702\u20130.980). Full vaccination achieved even greater reductions in in-hospital, 90-day, and 1-year mortality (HR 0.638, 95% CI 0.479\u20130.851; HR 0.702, 95% CI 0.592\u20130.833; and HR 0.815, 95% CI 0.713\u20130.931, respectively). Subgroup analysis based on patient-related characteristics demonstrated the consistence of vaccination with long-term survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In HF patients, seasonal influenza vaccination appears to be associated with less severe decompensation and lower 1-year mortality, while no firm conclusions can be drawn from the results of the present study regarding the benefits of COVID-19 vaccination. Full vaccination is associated with the greatest reduction in short- and long-term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3469","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T09:16:26Z","timestamp":1727169386000},"page":"152-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Seasonal Influenza and COVID-19 Vaccination on Severity and Long-Term Outcomes of Patients with Heart Failure Decompensations"],"prefix":"10.1093","volume":"27","author":[{"given":"\u00d2scar","family":"Mir\u00f3","sequence":"first","affiliation":[{"name":"Emergency Department, Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona , Barcelona ,","place":["Spain"]},{"name":"The GREAT Network , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Ivars","sequence":"additional","affiliation":[{"name":"Emergency Department, Short Stay Unit and Hospitalization at Home Unit, Hospital General de Alicante, Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), Universidad Miguel Hern\u00e1ndez , Alicante ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Emergency Department, Short Stay Unit and Hospitalization at Home Unit, Hospital General de Alicante, Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), Universidad Miguel Hern\u00e1ndez , Alicante ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Jacob","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitari de Bellvitge, l'Hospitalet de Llobregat , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aitor","family":"Alqu\u00e9zar-Arb\u00e9","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital de la Santa Creu i Sant Pau , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Pilar","family":"L\u00f3pez-D\u00edez","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitario de Burgos , Burgos ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Herrero Puente","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitario Central de Asturias , Oviedo ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"L\u00f3pez-Grima","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Doctor Peset , Valencia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitario Infanta Leonor , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Rodr\u00edguez Fuertes","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitario La Paz , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascual","family":"Pi\u00f1era Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Reina Sof\u00eda , Murcia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Tost","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital de Terrasssa , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Andueza","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Doctor Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Domingo Baldrich","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitari Vall d'Hebron , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Garrido","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Virgen de la Macarena , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Noceda","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Cl\u00ednico de Valencia , Valencia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Lucas-Imbernon","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital General de Albacete , Albacete ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Moyano Garc\u00eda","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Comarcal Valle de los Pedroches , Pozoblanco ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Gil","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Masip","sequence":"additional","affiliation":[{"name":"The GREAT Network , Rome ,","place":["Italy"]},{"name":"Research Department, Consorci Sanitari Integral , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Frank","family":"Peacock","sequence":"additional","affiliation":[{"name":"The GREAT Network , Rome ,","place":["Italy"]},{"name":"Emergency Department, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"The GREAT Network , Rome ,","place":["Italy"]},{"name":"Cardiology Department, University Hospital of Basel, Cardiovascular Research Institute Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Llorens","sequence":"additional","affiliation":[{"name":"Emergency Department, Short Stay Unit and Hospitalization at Home Unit, Hospital General de Alicante, Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), Universidad Miguel Hern\u00e1ndez , Alicante ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the 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