{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:27:28Z","timestamp":1788550048886,"version":"build-2803163510"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":449,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010447","name":"German Center for Cardiovascular Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005971","name":"German Heart Foundation\/German Foundation of Heart Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Traditional cardiovascular (CV) biomarkers (high-sensitivity troponinT [hsTnT] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]) are important to monitor cancer patients' cardiac function and to assess prognosis. Newer CV biomarkers (mid-regional pro-adrenomedullin [MR-proADM], C-terminal pro-arginine vasopressin [copeptin], and mid-regional pro-atrial natriuretic peptide [MR-proANP]) might outperform traditional biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Overall, 442 hospitalized cancer patients without significant CV disease or current infection were enrolled (61\u2009\u00b1\u200915\u2009years, 52% male, advanced cancer stage: 85%) and concentrations of CV biomarkers were analysed. Differences in echocardiographic, clinical, laboratory parameters were assessed. Patients were followed for up to 69\u2009months for all-cause mortality. In univariable analyses, MR-proADM, hsTnT, copeptin, MR-proANP, and NT-proBNP predicted all-cause mortality. In multivariable analyses (adjusted for sex, age, Eastern Cooperative Oncology Group performance status, estimated glomerular filtration rate [eGFR], C-reactive protein, anti-cancer therapy, reason for hospitalization, cancer stage and type), only MR-proADM remained an independent predictor of mortality (MR-proADM per 1 ln: hazard ratio [HR] 2.27, 95% confidence interval [CI] 1.47\u20133.50], p\u2009&amp;lt;\u20090.001). MR-proADM had the highest area under the curve (AUC) using receiver operating characteristic analysis (AUC [95% CI] 0.74 [0.69\u20130.79]; hsTnT: AUC 0.69; copeptin: AUC 0.66; MR-proANP: AUC 0.63; NT-proBNP: AUC 0.62). Optimal cut-point for mortality prediction with MR-proADM was 0.94\u2009nmol\/L (HR 2.43 [95% CI 1.92\u20133.06], p\u2009&amp;lt;\u20090.001). Patients with MR-proADM &amp;gt;0.94\u2009nmol\/L were older, more often had cancer stage IV, showed reduced performance status, eGFR, haemoglobin, diastolic left ventricular function, and elevated systolic pulmonary artery pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MR-proADM is an independent predictor of mortality in advanced stage, hospitalized cancer patients without significant CV disease or current infection. The optimal MR-proADM cut-point for mortality prediction was 0.94\u2009nmol\/L with hazards for mortality being approximately 2.5 times higher. There was a continuous increase in mortality risk with stepwise increase of MR-proADM concentrations. Elevated concentrations of MR-proADM were also associated with reduced performance status and mildly reduced left ventricular diastolic function as well as higher age and more often cancer stage IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3497","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T02:20:22Z","timestamp":1732674022000},"page":"1047-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Cardiovascular Biomarkers in Patients with Advanced Cancer \u2013 A Prospective Study Comparing MR-proADM, MR-proANP, Copeptin, High-Sensitivity Troponin T and NT-proBNP"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-8555","authenticated-orcid":false,"given":"Markus S.","family":"Anker","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 University Medicine Berlin corporate member of Free University Berlin, and Humboldt-University Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Campus Benjamin Franklin, German Heart Center Charit\u00e9 , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"L\u00fcck","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 University Medicine Berlin corporate member of Free University Berlin, and Humboldt-University Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Clinic, German Heart Center Charit\u00e9 , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke University Medical Center , Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Porthun","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 University Medicine Berlin corporate member of Free University Berlin, and Humboldt-University Berlin , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Clinic, German Heart Center Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Norwegian University of Science and Technology , Gj\u00f8vik ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hadzibegovic","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 University Medicine Berlin corporate member of Free University Berlin, and Humboldt-University Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Campus Benjamin Franklin, German Heart Center Charit\u00e9 , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Lena","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 University Medicine Berlin corporate member of Free University Berlin, and Humboldt-University Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT) , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Campus Benjamin Franklin, German Heart Center Charit\u00e9 , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Wilkenshoff","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 University Medicine Berlin corporate member of Free University Berlin, and Humboldt-University Berlin , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Campus Benjamin Franklin, German Heart Center Charit\u00e9 , Berlin 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Cardiovascular Research (DZHK), partner site G\u00f6ttingen , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Totzeck","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen , Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Mahabadi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen , Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienush","family":"Rassaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen , Essen 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University Berlin, Humboldt-University Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Keller","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK), partner site Berlin, a partnership between DKFZ and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Department of Hematology, Oncology and Cancer, Immunology, Charit\u00e9 \u2013 University Medicine Berlin, Campus Benjamin Franklin , Berlin ,","place":["Germany"]},{"name":"Max Delbr\u00fcck Center , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahir","family":"Karakas","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research, partner site HH\/Kiel\/HL , Hamburg ,","place":["Germany"]},{"name":"Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf , Hamburg 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