{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:26:49Z","timestamp":1790742409861,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":478,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["2004045806"],"award-info":[{"award-number":["2004045806"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009945","name":"Merck, Sharp & Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009761","name":"Hulda och E Conrad Mossfelts Stiftelse f\u00f6r Vetenskaplig Forskning Inom Hj\u00e4rt- och K\u00e4rlsjukdomarnas Omr\u00e5de","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009748","name":"Ernhold Lundstr\u00f6ms stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5nes universitetssjukhus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Craaford Foundation"},{"name":"The Wallenberg Center for Molecular Medicine"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["2004045806"],"award-info":[{"award-number":["2004045806"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009761","name":"Hulda och E Conrad Mossfelts Stiftelse f\u00f6r Vetenskaplig Forskning Inom Hj\u00e4rt- och K\u00e4rlsjukdomarnas Omr\u00e5de","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009748","name":"Ernhold Lundstr\u00f6ms stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5nes universitetssjukhus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart failure (HF). We explored the association between proteomic biomarkers and left ventricular hypertrophy (LVH), diastolic dysfunction (DD) and incident HF in three population-based cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A chip was used to measure 92 protein biomarkers in blood samples from &amp;gt;1500 Malm\u00f6 Preventive Project (MPP) participants, of whom 514 had LVH (34%), 462 had DD (32.4%) and, over a median follow-up of 13 (11\u201314) years, 130 developed HF (7.7%). Findings were confirmed in the STANISLAS (n\u2009&amp;gt;\u20091500, 238 participants with LVH, 76 with DD) and HOMAGE case-control (562 cases of incident HF, 871 controls) cohorts. In multivariable logistic or Cox regression analyses adjusted for age, sex and cardiovascular risk factors, N-terminal pro-B-type natriuretic peptide (NT-proBNP) was associated with LVH, DD and incident HF in all cohorts: MPP (LVH odds ratio [OR] [95% confidence interval] 1.48 [1.28\u20131.71]; DD OR 1.71 [1.53\u20131.92]; HF HR 1.98 [1.66\u20132.36]); STANISLAS (LVH OR 1.20 [1.02\u20131.41]; DD OR 1.46 [1.12\u20131.90]); HOMAGE (HF HR 1.85 [1.62\u20132.12]). Galectin-4, growth differentiation factor 15 and suppression of tumorigenicity-2 were associated with incident HF in MPP and HOMAGE. A pathway enrichment analysis suggested that inflammation and viral infection were related to incident HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, our study reinforces the role of NT-proBNP as a key biomarker for asymptomatic cardiac dysfunction and incident HF, consistent with its established use in clinical practice. This underscores the value of NT-proBNP for identifying patients at high risk for HF, and provides insights into pathways leading to HF and potential therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3502","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T14:14:41Z","timestamp":1730124881000},"page":"1764-1774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Proteomic Biomarkers and Pathway Analysis for Progression to Heart Failure in Three Epidemiological Representative Cohorts"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-937X","authenticated-orcid":false,"given":"Anna","family":"Dieden","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Biomedical Science, Malm\u00f6 University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Biofilms Research Centre for Biointerfaces, Malm\u00f6 University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d'Investigations Cliniques Plurith\u00e9matique 1433, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1116, Centre Hospitalier Universitaire R\u00e9gional de Nancy , Nancy ,","place":["France"]},{"name":"French Clinical Research Infrastructure Network \u2018Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists\u2019 Cardiovascular and Renal Clinical Trialists Network , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Ottosson","sequence":"additional","affiliation":[{"name":"Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Molvin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manan","family":"Pareek","sequence":"additional","affiliation":[{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Internal Medicine, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmus","family":"Bachus","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"R\u00e5stam","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Institute of Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bledar","family":"Daka","sequence":"additional","affiliation":[{"name":"Institute of Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margr\u00e9t","family":"Le\u00f3sd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Internal Medicine, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark , Odense ,","place":["Denmark"]},{"name":"Department of Internal Medicine 1 and Steno Diabetes Center Zealand, Holbaek Hospital , Holbaek ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Hull York Medical School, Castle Hill Hospital , Cottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Delles","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Program of Cardiovascular Diseases, Centre for Applied Medical Research (CIMA), and Department of Cardiology and Cardiac Surgery, Cl\u00ednica Universidad de Navarra, University of Navarra , Pamplona ,","place":["Spain"]},{"name":"CIBERCV, Carlos III Institute of Health , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA) , Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohra","family":"Lamiral","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d'Investigations Cliniques Plurith\u00e9matique 1433, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1116, Centre Hospitalier Universitaire R\u00e9gional de Nancy , Nancy ,","place":["France"]},{"name":"French Clinical Research Infrastructure Network \u2018Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists\u2019 Cardiovascular and Renal Clinical Trialists Network , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Duarte","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d'Investigations Cliniques Plurith\u00e9matique 1433, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1116, Centre Hospitalier Universitaire R\u00e9gional de Nancy , Nancy ,","place":["France"]},{"name":"French Clinical Research Infrastructure Network \u2018Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists\u2019 Cardiovascular and Renal Clinical Trialists Network , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d'Investigations Cliniques Plurith\u00e9matique 1433, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1116, Centre Hospitalier Universitaire R\u00e9gional de Nancy , Nancy ,","place":["France"]},{"name":"French Clinical Research Infrastructure Network \u2018Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists\u2019 Cardiovascular and Renal Clinical Trialists Network , Nancy ,","place":["France"]},{"name":"Medical Specialties and Nephrology Departments, Princess Grace Hospital and Monaco Private Hemodialysis Center , Monaco ,","place":["Monaco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d'Investigations Cliniques Plurith\u00e9matique 1433, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1116, Centre Hospitalier Universitaire R\u00e9gional de Nancy , Nancy ,","place":["France"]},{"name":"French Clinical Research Infrastructure Network \u2018Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists\u2019 Cardiovascular and Renal Clinical Trialists Network , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"Gudmundsson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Malm\u00f6 University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Biofilms Research Centre for Biointerfaces, Malm\u00f6 University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amra","family":"Juji\u0107","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]},{"name":"Hypertension in Africa Research Team (HART), North West University , Potchefstroom ,","place":["South Africa"]},{"name":"Wallenberg Center for Molecular Medicine, Lund University , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"2026021721455340700_ejhf3502-bib-0001","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1093\/eurheartj\/ehab082","article-title":"The struggle towards a universal definition of heart failure-how to proceed?","volume":"42","author":"Cleland","year":"2021","journal-title":"Eur Heart J"},{"key":"2026021721455340700_ejhf3502-bib-0002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0003","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jchf.2015.09.015","article-title":"Assessing the risk of progression from asymptomatic left ventricular dysfunction to overt heart failure: A systematic overview and meta-analysis","volume":"4","author":"Echouffo-Tcheugui","year":"2016","journal-title":"JACC Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0004","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.jacc.2008.09.014","article-title":"The relationship of left ventricular mass and geometry to incident cardiovascular events: The MESA (Multi-Ethnic Study of Atherosclerosis) study","volume":"52","author":"Bluemke","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026021721455340700_ejhf3502-bib-0005","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007849","article-title":"Comprehensive proteomics profiling reveals circulating biomarkers of hypertrophic cardiomyopathy","volume":"14","author":"Shimada","year":"2021","journal-title":"Circ Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0006","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005897","article-title":"Proteomic bioprofiles and mechanistic pathways of progression to heart failure","volume":"12","author":"Ferreira","year":"2019","journal-title":"Circ Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0007","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.122.009694","article-title":"Protein biomarkers of new-onset heart failure: Insights from the Heart Omics and Ageing cohort, the Atherosclerosis Risk in Communities study, and the Framingham Heart Study","volume":"16","author":"Girerd","year":"2023","journal-title":"Circ Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0008","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ejhf.980","article-title":"Circulating proteins as predictors of incident heart failure in the elderly","volume":"20","author":"Stenemo","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0009","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1038\/s41467-019-13306-y","article-title":"Profiling of the plasma proteome across different stages of human heart failure","volume":"10","author":"Egerstedt","year":"2019","journal-title":"Nat Commun"},{"key":"2026021721455340700_ejhf3502-bib-0010","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ahj.2009.12.028","article-title":"Myocardial structure and function by echocardiography in relation to glucometabolic status in elderly subjects from 2 population-based cohorts: A cross-sectional study","volume":"159","author":"Leosdottir","year":"2010","journal-title":"Am Heart J"},{"key":"2026021721455340700_ejhf3502-bib-0011","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/ije\/dyx240","article-title":"Cohort profile: Rationale and design of the fourth visit of the STANISLAS cohort: A familial longitudinal population-based cohort from the Nancy region of France","volume":"47","author":"Ferreira","year":"2018","journal-title":"Int J Epidemiol"},{"key":"2026021721455340700_ejhf3502-bib-0012","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005231","article-title":"Risk for incident heart failure: A subject-level meta-analysis from the Heart \u2018Omics\u2019 in AGEing (HOMAGE) study","volume":"6","author":"Jacobs","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2026021721455340700_ejhf3502-bib-0013","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euje.2005.12.014","article-title":"Recommendations for chamber quantification","volume":"7","author":"Lang","year":"2006","journal-title":"Eur J Echocardiogr"},{"key":"2026021721455340700_ejhf3502-bib-0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"2026021721455340700_ejhf3502-bib-0015","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"2026021721455340700_ejhf3502-bib-0016","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/ejhf.1716","article-title":"Effects of spironolactone on serum markers of fibrosis in people at high risk of developing heart failure: Rationale, design and baseline characteristics of a proof-of-concept, randomised, precision-medicine, prevention trial. The Heart OMics in AGing (HOMAGE) trial","volume":"22","author":"Pellicori","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0017","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"2026021721455340700_ejhf3502-bib-0018","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jcmg.2021.07.004","article-title":"Machine learning-derived echocardiographic phenotypes predict heart failure incidence in asymptomatic individuals","volume":"15","author":"Kobayashi","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026021721455340700_ejhf3502-bib-0019","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/sim.4085","article-title":"Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers","volume":"30","author":"Pencina","year":"2011","journal-title":"Stat Med"},{"key":"2026021721455340700_ejhf3502-bib-0020","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ejhf.2488","article-title":"Only people with increased plasma concentrations of natriuretic peptides should be included in outcome trials of diabetes, cardiovascular and kidney disease: Implications for clinical practice","volume":"24","author":"Cleland","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0021","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012336","article-title":"Cardiac biomarkers and risk of incident heart failure in chronic kidney disease: The CRIC (Chronic Renal Insufficiency Cohort) study","volume":"8","author":"Bansal","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2026021721455340700_ejhf3502-bib-0022","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S2213-8587(16)30196-6","article-title":"Natriuretic peptides and integrated risk assessment for cardiovascular disease: An individual-participant-data meta-analysis","volume":"4","author":"Willeit","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026021721455340700_ejhf3502-bib-0023","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.jacc.2013.05.069","article-title":"PONTIAC (NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease): A prospective randomized controlled trial","volume":"62","author":"Huelsmann","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026021721455340700_ejhf3502-bib-0024","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.jacc.2021.12.011","article-title":"2022 AHA\/ACC\/HFSA Guideline for the management of heart failure: Executive summary: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026021721455340700_ejhf3502-bib-0025","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003188","article-title":"Soluble ST2 for prediction of heart failure and cardiovascular death in an elderly, community-dwelling population","volume":"5","author":"Parikh","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2026021721455340700_ejhf3502-bib-0026","article-title":"Plasma protein profile of incident myocardial infarction, ischemic stroke, and heart failure in 2 cohorts","volume":"10","author":"Lind","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026021721455340700_ejhf3502-bib-0027","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009555","article-title":"Temporal patterns of 14 blood biomarker candidates of cardiac remodeling in relation to prognosis of patients with chronic heart failure \u2013 The Bio-SHiFT study","volume":"8","author":"Bouwens","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2026021721455340700_ejhf3502-bib-0028","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1002\/ehf2.13036","article-title":"Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease","volume":"7","author":"Molvin","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2026021721455340700_ejhf3502-bib-0029","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","article-title":"Inflammation in heart failure: JACC state-of-the-art review","volume":"75","author":"Murphy","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026021721455340700_ejhf3502-bib-0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","article-title":"Myocarditis and inflammatory cardiomyopathy: Current evidence and future directions","volume":"18","author":"Tschope","year":"2021","journal-title":"Nat Rev Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/27\/9\/1764\/66834371\/eurjhf_27_9_1764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/27\/9\/1764\/66834371\/eurjhf_27_9_1764.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:46:13Z","timestamp":1771382773000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/27\/9\/1764\/8468062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,10,28]]},"published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.3502","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}