{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:32:11Z","timestamp":1777501931362,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate clinical outcomes, echocardiographic features, and the efficacy and safety of sacubitril\/valsartan compared to valsartan across age groups in the PARAGON-HF trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 4796 participants \u226550\u2009years of age with chronic heart failure (HF) and left ventricular ejection fraction (LVEF)\u2009\u226545% were divided into three age groups: &amp;lt;65\u2009years (n\u2009=\u2009825), 65\u201374\u2009years (n\u2009=\u20091772), and\u2009\u226575\u2009years (n\u2009=\u20092199). Echocardiograms of 1097 patients were analysed in a standardized fashion at a core imaging laboratory. The primary composite outcome was total HF hospitalizations and cardiovascular (CV) death. Older patients were more likely to experience primary composite outcomes (compared to patients &amp;lt;65\u2009years, adjusted rate ratio [aRR] for \u226575\u2009years: 1.39, 95% confidence interval [CI] 1.21\u20131.61), total HF hospitalization (aRR 1.27, 95% CI 1.09\u20131.49), and CV death (adjusted hazard ratio [aHR] 2.04, 95% CI 1.44\u20132.87). Age did not modify the effect of sacubitril\/valsartan compared to valsartan on primary composite endpoint (pinteraction\u2009=\u20090.79) in the overall population or in those with LVEF \u226457%. Older adults randomized to sacubitril\/valsartan were more likely to develop hypotension compared to those receiving valsartan (pinteraction\u2009=\u20090.026). Older patients had smaller left ventricular chamber sizes, higher LVEF, and were more likely to have abnormal measures of diastolic function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older patients with HF with preserved ejection fraction had higher event rates than younger patients, more adverse events overall, and more hypotension when treated with sacubitril\/valsartan; however, the treatment benefits of sacubitril\/valsartan were retained in older patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3535","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T20:39:41Z","timestamp":1734295181000},"page":"96-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Sacubitril\/Valsartan in Heart Failure with Preserved Ejection Fraction Across the Age Spectrum in PARAGON-HF"],"prefix":"10.1093","volume":"27","author":[{"given":"Xiaowen","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orly","family":"Vardeny","sequence":"additional","affiliation":[{"name":"Minneapolis VA Center for Care Delivery and Outcomes Research University of Minnesota , Minneapolis, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthiah","family":"Vaduganathan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila M.","family":"Hegde","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hicham","family":"Skali","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Pabon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Fo\u00e0","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]},{"name":"Cardiology Unit, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safia","family":"Chatur","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Kosztin","sequence":"additional","affiliation":[{"name":"Semmelweis University Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"O'Meara","sequence":"additional","affiliation":[{"name":"Universite de Montreal , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Universite de Montreal , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Redfield","sequence":"additional","affiliation":[{"name":"Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn S.P.","family":"Lam","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Duke-NUS Medical School , Singapore ,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Zile","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina , Carleston, SC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton","family":"Packer","sequence":"additional","affiliation":[{"name":"Baylor University Medical Center , Dallas, TX ,","place":["USA"]},{"name":"Imperial College , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amil M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Texas Southwestern Medical Center , Dallas, TX ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Cikes","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb , Zagreb ,","place":["Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Gori","sequence":"additional","affiliation":[{"name":"Cardiology Division, Cardiovascular Department, Papa Giovanni XXIII Hospital , Bergamo ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Merkely","sequence":"additional","affiliation":[{"name":"Semmelweis University Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc 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