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    <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with SLD without a history of HF from 2006 to 2021 were retrospectively included and were classified into MASLD and non-MASLD groups that were followed longitudinally. The primary outcome was the new development of HF, which was sub-classified by echocardiography. Multivariable and propensity score matching analyses were conducted to adjust for confounding factors. Overall, 26\u2009676 patients with SLD were included, with a median age of 51\u2009years and 71% classified as MASLD. During a median follow-up of 6\u2009years, 429 (1.61%) patients developed HF, and 76% were HF with preserved ejection fraction (HFpEF). The risk of HF was significantly higher in patients with MASLD than in those without (sub-distribution hazard ratio [SHR] 2.59, 95% confidence interval [CI] 1.84\u20133.64) after adjustment of competing mortality. There was a dose-dependent increase in HF risks in patients with more cardiometabolic risk factors (SHR 1.12, 95% CI 1.04\u20131.22). MASLD was also associated with higher risk of HF-related hospitalization (SHR 2.30, 95% CI 1.31\u20134.04) and specifically, the risk of HFpEF (SHR 1.91, 95% CI 1.27\u20132.86). In propensity score-matched cohorts, MASLD was also associated with a 2.52-fold higher risk of HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with SLD, those with MASLD show a higher risk of HF, specifically HFpEF. Future studies are warranted to validate the association between HF and MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3567","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T03:01:46Z","timestamp":1736305306000},"page":"512-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Metabolic Dysfunction-Associated Steatotic Liver Disease is Associated with Increased Risks of Heart Failure"],"prefix":"10.1093","volume":"27","author":[{"given":"Kai-Chun","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-7941","authenticated-orcid":false,"given":"Tung-Hung","family":"Su","sequence":"additional","affiliation":[{"name":"Division of 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