{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:15:08Z","timestamp":1792052108133,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the association between transcatheter edge-to-edge repair (TEER) and outcomes in patients with significant mitral regurgitation (MR) following acute myocardial infarction (MI), focusing on the aetiology of acute post-MI MR in high-risk surgical patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The International Registry of MitraClip in Acute Mitral Regurgitation following Acute Myocardial Infarction (IREMMI) includes 187 patients with severe MR post-MI managed with TEER. Of these, 176 were included in the analysis, 23 (13%) patients had acute papillary muscle rupture (PMR) and 153 (87%) acute secondary MR. The mean age was 70\u2009\u00b1\u200910\u2009years and 41% were female. PMR patients had fewer cardiovascular risk factors: hypertension (52% vs. 73%, p\u2009=\u20090.04), diabetes (26% vs. 48%, p\u2009&amp;lt;\u20090.01) but a higher left ventricular ejection fraction (45\u00b1\u2009\u200915% vs.35\u00b1\u2009\u200910%, p\u2009&amp;lt;\u20090.01) compared secondary MR patients. PMR patients were more likely to present in cardiogenic shock (91% vs. 51%, p\u2009=\u20090.001), require mechanical circulatory support (74% vs. 34%, p\u2009=\u20090.01), and had a higher EuroSCORE II (23\u00b1\u2009\u200913% vs. 13\u00b1\u2009\u200911%, p\u2009=\u20090.011). The median time from MI to TEER was shorter in PMR (6\u2009days) versus secondary MR (20\u2009days) (p\u2009&amp;lt;\u20090.01). Procedural success was similar (87% vs. 92%, p\u2009=\u20090.49) with comparable MR grade reduction. However, PMR patients had significantly higher in-hospital mortality rates (adjusted odds ratio [OR] 3.05, 95% confidence interval [CI] 1.15\u20138.12, p\u2009=\u20090.02), 30-day mortality rates (unadjusted OR 3.99, 95% CI 1.42\u201311.26, p\u2009=\u20090.01) and a higher rate of conversion to surgical mitral valve replacement (22% vs. 3%, p\u2009&amp;lt;\u20090.01) (unadjusted OR 8.17, 95% CI 2.15\u201330.96, p\u2009&amp;lt;\u20090.001). Aetiology of MR, cardiogenic shock, and procedure timing significantly impacted in-hospital mortality. After adjusting for EuroSCORE II and cardiogenic shock, MR aetiology remained the strongest predictor (adjusted OR 6.71; 95% CI 2.06\u201321.86, p\u2009&amp;lt;\u20090.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transcatheter edge-to-edge repair may be considered a salvage or bridge procedure in decompensated post-MI MR patients of both aetiologies; however, patients with PMR have a higher risk of mortality and conversion to surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3582","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T22:34:56Z","timestamp":1736894096000},"page":"912-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Transcatheter Edge-To-Edge Repair in Severe Mitral Regurgitation Following Acute Myocardial Infarction \u2013 Aetiology-Based Analysis"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-8919","authenticated-orcid":false,"given":"Dan","family":"Haberman","sequence":"first","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot. 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