{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:44:42Z","timestamp":1793094282040,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":311,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The prognostic significance of detecting left ventricular (LV) systolic dysfunction during family screening programmes (FSPs) in relatives of probands affected by dilated (DCM) and non-dilated left ventricular (NDLVC) cardiomyopathies remain unclear. This study sought to evaluate the prognostic role of LV systolic dysfunction detection in relatives of DCM\/NDLVC probands and to define the most accurate FSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Baseline and follow-up data of first-degree relatives of probands affected by DCM\/NDLVC were collected. The primary outcome was all-cause death and heart transplantation. Secondary heart failure (HF) and arrhythmic outcomes were also included. A total of 492 first degree relatives were enrolled. During a median follow-up of 110\u2009months (interquartile range 57\u2013188\u2009months), only subjects that previously developed LV systolic dysfunction had primary outcomes (19 vs. 0, p\u2009&amp;lt;\u20090.001) and secondary outcomes (HF: 12 vs. 0, p\u2009=\u20090.005; arrhythmic: 30 vs. 0, p\u2009&amp;lt;\u20090.001). Subjects with LV systolic dysfunction detected by FSP showed lower rate of primary outcomes (FSP: n\u2009=\u200919 [14%]; no-FSP: n\u2009=\u200940 [37%]; p\u2009&amp;lt;\u20090.001) and secondary arrhythmic outcomes (FSP: n\u2009=\u200918 [13%]; no-FSP: n\u2009=\u200941 [38%]; p\u2009&amp;lt;\u20090.001). In this setting, family history of arrhythmia and being carrier of a pathogenic\/likely pathogenic variant are the main risk factors for LV systolic dysfunction, while LV global longitudinal strain (LV-GLS) and Holter electrocardiogram (ECG) showed a relevant role in terms of prediction of LV systolic dysfunction and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Relatives of DCM\/NDLVC probands who developed LV systolic dysfunction during a long follow-up had a significant increased risk of major adverse cardiovascular outcomes. However, LV systolic dysfunction detected by FSP showed a better prognosis. In this context, genetics, Holter ECG and LV-GLS demonstrated their functional role for disease and event prediction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3657","type":"journal-article","created":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T21:31:11Z","timestamp":1744579871000},"page":"3260-3268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prediction and Prognostic Role of Left Ventricular Systolic Dysfunction in Family Screening for Dilated Cardiomyopathy and Non-Dilated Left Ventricular Cardiomyopathy"],"prefix":"10.1093","volume":"27","author":[{"given":"Eva","family":"Del Mestre","sequence":"first","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]},{"name":"European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Paldino","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]},{"name":"European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Pio Loco Detto Gava","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]},{"name":"European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Gandin","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Department of Medicine, Surgery and Health Science, University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gigli","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]},{"name":"European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Stolfo","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]},{"name":"European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Setti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardio-Thoracic Department, University Hospital of Verona , Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Maria","family":"Severini","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health \u2013 IRCCS \u2018Burlo Garofolo\u2019 , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Spedicati","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health \u2013 IRCCS \u2018Burlo Garofolo\u2019 , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Lenarduzzi","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health \u2013 IRCCS \u2018Burlo 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Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]},{"name":"European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Korcova","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]},{"name":"European Reference Network for rare, low-prevalence, or complex diseases of the Heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Mestroni","sequence":"additional","affiliation":[{"name":"Molecular Genetics, Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO 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