{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:08:08Z","timestamp":1792858088670,"version":"4.5.0"},"reference-count":210,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":290,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute myocardial infarction (MI) remains a major cause of death and disability worldwide. No adjuvant treatment has yet been fully validated in patients to limit the progression from the initial tissue damage due to acute MI, to the development of heart failure. However, mitochondria have long been demonstrated to be a key target for cardioprotective strategies to reduce cell death that leads to left ventricular dysfunction and ultimately heart failure. While pre-clinical studies have investigated several mitoprotective strategies targeting different mitochondrial functions, such as oxidative stress or permeability transition pore opening, none have shown successful clinical translation so far. In this European Society of Cardiology scientific statement, we present recent research advances in the understanding of the mitochondrial alterations occurring in MI and in the discovery of key components of mitochondrial structure and function in order to improve drug development. We discuss the reasons for the failure of clinical translation and the remaining obstacles that need to be addressed, including timing of drug administration, tissue bioavailability and efficient mitochondrial targeting, together with the mitochondrial impact derived from risk factors, comorbidities and comedications. Taken together, this scientific statement aims to provides a consensus opinion from clinicians and basic scientists to translate some of the most promising mitoprotective targets into the clinical setting to protect against MI and heart failure.<\/jats:p>","DOI":"10.1002\/ejhf.3674","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:35:12Z","timestamp":1746390912000},"page":"1720-1736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mitochondrial Targets in Ischaemic Heart Disease and Heart Failure, and their Potential for a More Efficient Clinical Translation. A Scientific Statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function"],"prefix":"10.1093","volume":"27","author":[{"given":"Melanie","family":"Paillard","sequence":"first","affiliation":[{"name":"Laboratoire CarMeN-IRIS Team, INSERM, INRA, Universit\u00e9 Claude Bernard Lyon-1 , Bron ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abdellatif","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Medical University of Graz, BioTechMed Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, School of Pharmacy, National and Kapodistrian University of Athens , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"B\u00e4r","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Germany-Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Bertrand","sequence":"additional","affiliation":[{"name":"UCLouvain, Institute for Experimental and Clinical Research, Pole of Cardiovascular Research; WELBIO Department, WEL Research Institute , Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca J.J.M.","family":"Brundel","sequence":"additional","affiliation":[{"name":"Physiology, Amsterdam UMC Location Vrije Universiteit, Cardiovascular Sciences, Heart Failure and Arrhythmias , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Chiva-Blanch","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Universitat Oberta de Catalunya, Department of Endocrinology and Nutrition, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Cl\u00ednic of Barcelona , Barcelona ,","place":["Spain"]},{"name":"Biomedical Network Research Centre on Obesity and Nutrition Physiopathology (CIBEROBN), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Davidson","sequence":"additional","affiliation":[{"name":"The Hatter Cardiovascular Institute, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Dawson","sequence":"additional","affiliation":[{"name":"Aberdeen Cardiovascular and Diabetes Centre, School of Medicine and Dentistry, University of Aberdeen , Aberdeen ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Di Lisa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua , Padova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Evans","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Giricz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Semmelweis University , Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Hausenloy","sequence":"additional","affiliation":[{"name":"The Hatter Cardiovascular Institute, University College London , London ,","place":["UK"]},{"name":"National 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,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Rainer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Medical University of Graz, BioTechMed Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Streckfuss-B\u00f6meke","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of W\u00fcrzburg, Germany-Clinic for Cardiology and Pneumology, University Medicine G\u00f6ttingen, and German Center for Cardiovascular Research (DZHK), Partner site G\u00f6ttingen , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Thielmann","sequence":"additional","affiliation":[{"name":"West-German Heart & Vascular Center, University Duisburg-Essen , Essen 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