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While mitral valve transcatheter edge-to-edge repair (M-TEER) alleviates left-sided volume overload, its impact on right ventricular (RV) recovery is unclear. This study aims to use both conventional echocardiography and artificial intelligence to assess the recovery of RV function in patients undergoing M-TEER for severe MR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The change in RV function from baseline to 3-month follow-up was analysed in a dual-centre registry of patients undergoing M-TEER for severe MR. RV function was conventionally assessed by measuring the tricuspid annular plane systolic excursion (TAPSE). Additionally, RV function was evaluated using a deep learning model that predicts RV ejection fraction (RVEF) based on two-dimensional apical four-chamber view echocardiographic videos. Among the 851 patients who underwent M-TEER, the 1-year survival rate was 86.8%. M-TEER resulted in a significant reduction in both LA volume and estimated systolic pulmonary artery pressure (sPAP) levels (median LA volume: from 123\u2009ml [interquartile range, IQR 92\u2013169\u2009ml] to 104\u2009ml [IQR 78\u2013142\u2009ml], p\u2009&amp;lt;\u20090.001; median sPAP: from 46\u2009mmHg [IQR 35\u201358\u2009mmHg] to 41\u2009mmHg [IQR 32\u201354\u2009mmHg], p\u2009=\u20090.036). In contrast, TAPSE remained unchanged (median: from 17\u2009mm [IQR 14\u201321\u2009mm] to 18\u2009mm [IQR 15\u201321\u2009mm], p\u2009=\u20090.603). The deep learning model confirmed this finding, showing no significant change in predicted RVEF after M-TEER (median: from 43.1% [IQR 39.1\u201347.4%] to 43.2% [IQR 39.2\u201347.2%], p\u2009=\u20090.475).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While M-TEER improves left-sided haemodynamics, it does not lead to significant RV function recovery, as confirmed by both conventional echocardiography and artificial intelligence. This finding underscores the importance of treating patients before irreversible right heart damage occurs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3705","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:58:55Z","timestamp":1749459535000},"page":"2452-2464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Employment of Artificial Intelligence for an Unbiased Evaluation Regarding the Recovery of Right Ventricular Function after Mitral Valve Transcatheter Edge-to-Edge Repair"],"prefix":"10.1093","volume":"27","author":[{"given":"Vera","family":"Fortmeier","sequence":"first","affiliation":[{"name":"Department of General and Interventional Cardiology, Heart and Diabetes Center Northrhine-Westfalia, Ruhr University Bochum , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelie","family":"Hesse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Klinikum rechts der Isar, TUM University Hospital, School of Medicine and Health, Technical University of Munich , Munich ,","place":["Germany"]},{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Trenkwalder","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]},{"name":"Department of Cardiovascular Diseases, German Heart Center Munich, School of Medicine and Health, TUM University Hospital, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rton","family":"Tokodi","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rippen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Klinikum rechts der Isar, TUM University Hospital, School of Medicine and Health, Technical University of Munich , Munich ,","place":["Germany"]},{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jule","family":"Tervooren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Klinikum rechts der Isar, TUM University Hospital, School of Medicine and Health, Technical University of Munich , Munich ,","place":["Germany"]},{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Fett","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, Heart and Diabetes Center Northrhine-Westfalia, Ruhr University Bochum , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Harmsen","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Johannesburg , Auckland Park ,","place":["South 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,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"von Scheidt","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]},{"name":"Department of Cardiovascular Diseases, German Heart Center Munich, School of Medicine and Health, TUM University Hospital, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand","family":"Roski","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, German Heart Center Munich, School of Medicine and Health, TUM University Hospital, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Ger\u00e7ek","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, Heart and Diabetes Center Northrhine-Westfalia, Ruhr University Bochum , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, McGill University , Montreal ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Patrick","family":"Mayr","sequence":"additional","affiliation":[{"name":"Institute of Anesthesiology, German Heart Center Munich, School of Medicine and Health, TUM University Hospital, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erion","family":"Xhepa","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]},{"name":"Department of Cardiovascular Diseases, German Heart Center Munich, School of Medicine and Health, TUM University Hospital, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Klinikum rechts der Isar, TUM University Hospital, School of Medicine and Health, Technical University of Munich , Munich ,","place":["Germany"]},{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich ,","place":["Germany"]},{"name":"Department of Cardiovascular Diseases, German Heart Center Munich, School of Medicine and Health, TUM University Hospital, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, Heart and Diabetes Center Northrhine-Westfalia, Ruhr University Bochum , Bad Oeynhausen 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