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This problem involving the \u2018translation\u2019 of basic scientific findings into clinical applications and potential treatments or biomarkers for a condition like heart failure is widely recognized both in academia and industry. Despite the attempts that have been made by both sides to improve this situation, the high attrition rates of drug development and the problem with reproducibility and translatability of preclinical findings to human applications still persist. As a result, the return on investment of basic research has been limited in terms of clinical impact. In this scientific statement we describe and discuss various issues with relevance to this theme and try to dissect how to move our field towards the development of more effective heart failure drugs. We zoom in on facilitating the process of heart failure drug development, the unnecessary gaps (\u2018valley of death\u2019) between the critical steps in heart failure drug development, validation and de-validation of new concepts as early as possible (\u2018rigorous translation\u2019). We describe forums on how to stimulate cross-talk and interaction between clinician-scientists, basic heart failure researchers, biotech and industry, and how to enable them to speak the same language, and lessons learned from successes outside the heart failure field.<\/jats:p>","DOI":"10.1002\/ejhf.3709","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:55:42Z","timestamp":1750226142000},"page":"1379-1392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["How to Facilitate Seamless Translation from Basic Concepts to New Heart Failure Drugs. A Scientific Statement of the Heart Failure Association of the ESC"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-688X","authenticated-orcid":false,"given":"Carlo Gabriele","family":"Tocchetti","sequence":"first","affiliation":[{"name":"Cardio-Pulmonary Onco-Immunology, Department of Translational Medical Sciences (DISMET), Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University , Naples ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Program of Cardiovascular Diseases, CIMA Universidad de Navarra, Department of Cardiology and Cardiac Surgery, Cl\u00ednica Universidad de Navarra, and IdiSNA Pamplona, Spain; CIBERCV, Carlos III Institute of Health , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Backs","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK), partner site Heidelberg\/Mannheim , Heidelberg ,","place":["Germany"]},{"name":"Institute of Experimental Cardiology, Medical Faculty Heidelberg, Heidelberg University, INF 669 , Heidelberg ,","place":["Germany"]},{"name":"Internal Medicine VIII, Heidelberg University Hospital, INF 669 , Heidelberg ,","place":["Germany"]},{"name":"Helmholtz Institute for Translational AngioCardioScience (HI-TAC), MDC at Heidelberg University , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Pollesello","sequence":"additional","affiliation":[{"name":"Critical Care, Orion Pharma , Espoo ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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