{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:27:15Z","timestamp":1785176835265,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiac wasting-associated cardiomyopathy in patients with advanced cancer is characterized by loss of left ventricular (LV) mass and independently associated with poor prognosis. Better understanding of this very prevalent cardiomyopathy is urgently needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Overall, 398 patients with active, mostly advanced cancer without significant cardiovascular disease (mean LV ejection fraction [LVEF] 64.3\u2009\u00b1\u20090.2%) or active infection were prospectively examined (mean age 60\u2009\u00b1\u20091\u2009years, 50% women, body mass index 25.0\u2009\u00b1\u20090.2\u2009kg\/m2, 26% cachectic). Patients were categorized and compared by quartiles of LV mass\/height2. LVEF, global longitudinal strain (GLS), and anticancer therapy naive status were similar across quartiles. Patients in Q1 (lowest LV mass quartile) were younger, more likely cachectic, had lower: BMI, 10-step stair-climbing power, tricuspid annular plane systolic excursion (TAPSE), stroke volume, cardiac output, and higher heart rate. In repeat follow-up assessments after 140\u2009\u00b1\u20098\u2009days (n\u2009=\u2009143), LVEF, TAPSE, LV mass, left atrial volume, and GLS were found reduced (all p\u2009\u2264\u20090.002). Only in those with above-median LV mass at baseline, cardiac output and heart rate increased during follow-up \u2013 in those with below-median LV mass, mitral E\/A decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with advanced cancer with low LV mass have a distinct phenotype characterized by lower cardiac chamber volumes, stroke volume, and cardiac output, but normal LVEF and GLS that may be the distinct feature of cardiac wasting-associated cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.3744","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T11:51:30Z","timestamp":1754481090000},"page":"2130-2140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Echocardiographic Phenotype of Cardiac Wasting in Patients with Advanced Cancer"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-8555","authenticated-orcid":false,"given":"Markus S.","family":"Anker","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 University Medicine Berlin corporate member of Free University Berlin and Humboldt-University Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research partner site Berlin, and Berlin Institute of Health Center for Regenerative Therapies , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology and Intensive Care Medicine CBF, German Heart Center Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Heart Hospital , Plano, Texas 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