{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:14:57Z","timestamp":1791054897824,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial flutter-related tachycardiomyopathy (AFL-TCM) is a rare and treatable cause of heart failure. Little is known about its epidemiology and long-term prognosis. Our aims are to determine the prevalence, predictors and outcomes of AFL-TCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 1269 patients were referred for radiofrequency ablation of AFL between January 1996 and September 2014; 184 had reduced left ventricular ejection fraction (LVEF &amp;lt;40%). At 6\u2009months after AFL ablation, 103 patients (8.1% of the population, 56% of patients with baseline LVEF &amp;lt;40%) had marked LVEF improvement: these were considered to have AFL-TCM. Patients with persisting reduced LVEF were considered to have systolic dysfunction unrelated to AFL. Patients were followed for a median (percentile25\u201375) of 1.15 (0.4\u20132.8) years. Patients with AFL-TCM were younger, had lower prevalence of ischaemic cardiomyopathy and used less antiarrhythmic drugs than patients with systolic dysfunction unrelated to AFL. In multivariable analysis, ischemic cardiomyopathy [odds ratio (OR)\u2009=\u20090.32, 95% confidence interval (CI) 0.15\u20130.68) P\u2009=\u20090.003] and prescription of antiarrhythmic drug before ablation [OR\u2009=\u20090.41, 95% CI 0.20\u20130.84, P\u2009=\u20090.02] were significantly associated with a lower probability of LVEF improvement during follow-up. Patients with AFL-TCM had similar survival to patients without systolic dysfunction at baseline [hazard ratio (HR)\u2009=\u20090.96 95% CI 0.34\u20132.65, P\u2009=\u20090.929], whereas patients with systolic dysfunction unrelated to AFL had higher mortality rates compared with patients without systolic dysfunction at baseline [HR\u2009=\u20092.88, 95% CI 1.45\u20135.72, P\u2009=\u20090.002].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Marked LVEF improvement was observed in 56% of patients with baseline LVEF &amp;lt;40% at 6\u2009months after ablation. These patients had similar survival to patients without baseline systolic dysfunction, whereas patients who remained with LVEF &amp;lt;40% had a threefold increase in mortality rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.482","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T03:58:27Z","timestamp":1454299107000},"page":"394-401","source":"Crossref","is-referenced-by-count":59,"title":["Predictors and Prognostic Significance of Tachycardiomyopathy: Insights from a Cohort of 1269 Patients Undergoing Atrial Flutter Ablation"],"prefix":"10.1093","volume":"18","author":[{"given":"B\u00e9atrice","family":"Brembilla-Perrot","sequence":"first","affiliation":[{"name":"Department of Cardiology Nancy University Hospital , Rue du Morvan 54511, Vandoeuvre-les-Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"INSERM, Centre d\u2019Investigations Cliniques Plurith\u00e9matique 1433, Universit\u00e9 de Lorraine , CHRU de Nancy and F-CRIN INI-CRCT, Nancy ,","place":["France"]},{"name":"Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto , Porto ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Manenti","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nancy University Hospital , Rue du Morvan 54511, Vandoeuvre-les-Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marc","family":"Sellal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nancy University Hospital , Rue du Morvan 54511, Vandoeuvre-les-Nancy 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