{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:01:51Z","timestamp":1791313311241,"version":"4.3.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess physicians\u2019 adherence to guideline-recommended medications for the treatment of chronic heart failure (CHF) with reduced ejection fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>QUALIFY is an international prospective observational longitudinal survey of 7092 CHF outpatients recruited 1\u201315\u2009months after hospitalization for heart failure from September 2013 to December 2014 in 547 centres in 36 countries. We constructed a five-class guideline adherence score for angiotensin converting enzyme inhibitors (ACEIs), beta-blockers, angiotensin receptor blockers (ARBs), mineralocorticoid receptor antagonists, and ivabradine. The adherence score was good in 67%, moderate in 25%, and poor in 8% of patients. Adherence was lower in women than men but there were differences in age (65.7\u2009\u00b1\u200912.5\u2009years women vs. 62.2\u2009\u00b1\u200912.4\u2009years men, P\u2009&amp;lt;\u20090.001) and the proportion of women at \u226550% target dose of beta-blockers was lower in those &amp;gt;67\u2009years (median) (11% vs. 16.2%, P\u2009=\u20090.005). Geographic variations were observed with lower adherence scores in Central\/Eastern European countries. The proportion of patients at target dose and \u226550% of target dose was low (27.9% and 63.3% for ACEIs, 14.8% and 51.8% for beta-blockers, 6.9% and 39.5% for ARBs, and 6.9% and 39.5% for ivabradine, respectively). It was also lower in patients most recently hospitalized (&amp;lt;6\u2009 vs. \u22656\u2009months) except for beta-blockers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This international survey shows that adherence to guideline-recommended medications is relatively satisfactory but the dosage of recommended CHF medications is usually suboptimal. Action plans aimed at improving adherence to guidelines are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.510","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T02:19:07Z","timestamp":1461118747000},"page":"514-522","source":"Crossref","is-referenced-by-count":228,"title":["Physicians\u2019 Adherence to Guideline-Recommended Medications in Heart Failure with Reduced Ejection Fraction: Data from the QUALIFY Global Survey"],"prefix":"10.1093","volume":"18","author":[{"given":"Michel","family":"Komajda","sequence":"first","affiliation":[{"name":"Institute of Cardiometabolism and Nutrition (ICAN), Pierre & Marie Curie Paris VI University, La Piti\u00e9-Salp\u00e9tri\u00e8re Hospital , AP-HP, 47-83 Boulevard de l\u2019H\u00f4pital, 75013, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Innovative Clinical Trials, Department of Cardiology & Pneumology, University Medical Centre G\u00f6ttingen (UMG) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Cowie","sequence":"additional","affiliation":[{"name":"Imperial College London, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos S.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Athens University Hospital Attikon , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Mengelle","sequence":"additional","affiliation":[{"name":"Department of Biometry , Lincoln, Boulogne-Billancourt ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Medical University, Faculty of Public Health , Wroclaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, GVM Care & Research, Ettore Sansavini Health Science Foundation , Cotignola ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"2026011721142967100_ejhf510-bib-0001","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/CIRCHEARTFAILURE.112.000161","article-title":"Multicenter prospective observational study on acute and chronic heart failure: the one-year follow-up results of IN-HF outcome registry","volume":"6","author":"Tavazzi","year":"2013","journal-title":"Circ Heart Fail"},{"key":"2026011721142967100_ejhf510-bib-0002","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/eurjhf\/hft050","article-title":"EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot)","volume":"15","author":"Maggioni","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026011721142967100_ejhf510-bib-0003","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/CIRCULATIONAHA.108.812172","article-title":"Long-term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people","volume":"119","author":"Jhund","year":"2009","journal-title":"Circulation"},{"key":"2026011721142967100_ejhf510-bib-0004","first-page":"803","article-title":"Developed in collaboration with the Heart Failure Association (HFA) of the ESC","volume":"14","author":"McMurray","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2026011721142967100_ejhf510-bib-0005","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1161\/CIRCULATIONAHA.109.192064","article-title":"2009 focused update: ACCF\/AHA Guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines developed in collaboration with the International Society for Heart and Lung Transplantation","volume":"119","author":"Jessup","year":"2009","journal-title":"Circulation"},{"key":"2026011721142967100_ejhf510-bib-0006","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0195-668X(02)00700-5","article-title":"The EuroHeart Failure Survey programme \u2013 a survey on the quality of care among patients with heart failure in Europe","volume":"24","author":"Komajda","year":"2003","journal-title":"Eur Heart J"},{"key":"2026011721142967100_ejhf510-bib-0007","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.ejheart.2007.09.008","article-title":"Is the gap between guidelines and clinical practice in heart failure treatment being filled? 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