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This study sought to evaluate the relationship between smoking and N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity Troponin T (hs-TnT), which are, respectively, biomarkers of myocardial wall stress and injury, in a large community-based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We examined the association between smoking history and NT-proBNP and hs-TnT in 9649 participants free of overt CAD or heart failure from the Atherosclerosis Risk in Communities (ARIC) Study who attended Visit 4 (1996\u20131998), as well as the association with change in these biomarkers from Visit 4 to Visit 5 (2011\u20132013) in 3151 participants. At Visit 4, higher cumulative cigarette exposure, assessed by total pack-years, was associated with elevated levels of NT-proBNP (P\u2009&amp;lt;\u20090.001) and hs-TnT (P\u2009=\u20090.01) among ever smokers in multivariable analyses adjusted for potential confounders. After 15\u2009years of follow-up, participants who were active smokers at Visit 4 had greater incidence of elevated NT-proBNP {adjusted proportion\u2009=\u200948% [95% confidence interval (CI) 41, 54] vs. 35 (95% CI 32, 39); P\u2009=\u20090.006} and hs-TnT [adjusted proportion\u2009=\u200932% (95% CI 26, 38) vs. 23 (95% CI 20, 26); P\u2009=\u20090.021] compared with never smokers, adjusting for baseline and follow-up covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a large community-based cohort free of overt CAD and heart failure, cigarette smoking was associated with biomarkers of myocardial wall stress and injury at baseline as well as with a continued measurable increase in these biomarkers after 15\u2009years of follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.511","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T17:58:47Z","timestamp":1459447127000},"page":"629-637","source":"Crossref","is-referenced-by-count":45,"title":["Influence of Cigarette Smoking on Cardiac Biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study"],"prefix":"10.1093","volume":"18","author":[{"suffix":"Jr","given":"Wilson","family":"Nadruz","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115 ,","place":["USA"]},{"name":"University of Campinas , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115 ,","place":["USA"]},{"name":"University of Porto Medical School , Porto ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Querejeta Roca","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amil M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Heiss","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of North Carolina , Chapel Hill, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Baylor College of Medicine and Houston Methodist DeBakey Heart and Vascular Center , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 75 Francis Street, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"2026011721145389400_ejhf511-bib-0001","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1161\/CIR.0b013e318260a20b","article-title":"Council on Nutrition, Physical Activity and Metabolism, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on the Kidney in Cardiovasc. 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