{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:33:48Z","timestamp":1768775628232,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Little is known about the clinical outcome and recurring system-related adverse events (SAE) in cardiac resynchronization therapy (CRT) patients after transvenous lead extraction (TLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From January 2009 to June 2014, 256 consecutive CRT patients (mean age 68.3 \u00b1 11.6 years, 216 male, 88% in New York Heart Association class II\u2013IV, ejection fraction 35.1 \u00b1 10.8%) were treated at four European institutions with TLE. Indications for TLE included systemic (18%) or local (45%) infection, system malfunction (34%), or other (3%). Demographic, clinical, TLE procedural, and follow-up data were collected retrospectively. Adverse events (AE) were considered as death from any cause, cardiovascular hospitalization, and SAE (SAE included pocket and\/or systemic infection, lead malfunction, or pocket haematoma requiring revision). Complete removal was achieved for 609 out of 614 leads (99.2%) by using either manual traction (28%), mechanical (52%) or laser (20%) sheaths. Over a median follow-up of 21 (interquartile range 12\u201329) months, cumulative incidences of any AE and SAE were 53.9% and 21.1%, respectively. Recurring system malfunction occurred in 23 patients (9.0%), infection in 16 patients (6.2%), and pocket haematoma requiring revision in 15 patients (5.9%). Oral anticoagulation therapy was an independent predictor of both any AE [hazard ratio (HR) 2.09, 95% confidence interval (CI) 1.35\u20133.22, P = 0.001] and SAE (HR 2.38, 95% CI 1.21\u20134.68, P = 0.012) after TLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Even though TLE is safe and effective to treat CRT patients, a high burden of recurring SAE after TLE was observed at mid-term follow-up. Careful evaluation of both patient characteristics as well as implantation strategy is suggested when indicating TLE in a CRT patient, particularly in patients receiving oral anticoagulation therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.558","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T02:28:26Z","timestamp":1463020106000},"page":"1270-1277","source":"Crossref","is-referenced-by-count":12,"title":["High Recurrence of Device-Related Adverse Events Following Transvenous Lead Extraction Procedure in Patients with Cardiac Resynchronization Devices"],"prefix":"10.1093","volume":"18","author":[{"given":"Fran\u00e7ois","family":"Regoli","sequence":"first","affiliation":[{"name":"Fondazione Cardiocentro Ticino, Department of Cardiology , Lugano ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Bongiorni","sequence":"additional","affiliation":[{"name":"Second Division of Cardiology, Cardiothoracic and Vascular Department, University Hospital of Pisa \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Rordorf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IRCCS, Fondazione Policlinico San Matteo , Pavia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Catholic University of the Sacred Heart , Campobasso ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterine","family":"Klersy","sequence":"additional","affiliation":[{"name":"Service of Biometry and Statistics, IRCCS, Fondazione Policlinico San Matteo , Pavia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Segreti","sequence":"additional","affiliation":[{"name":"Second Division of Cardiology, Cardiothoracic and Vascular Department, University Hospital of Pisa \u00a0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"De Regibus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IRCCS, Fondazione Policlinico San Matteo , Pavia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"Moccetti","sequence":"additional","affiliation":[{"name":"Fondazione Cardiocentro Ticino, Department of Cardiology , Lugano ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Conte","sequence":"additional","affiliation":[{"name":"Fondazione Cardiocentro Ticino, Department of Cardiology , Lugano ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luce","family":"Caputo","sequence":"additional","affiliation":[{"name":"Fondazione Cardiocentro Ticino, Department of Cardiology , Lugano ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Fondazione Cardiocentro Ticino, Department of Cardiology , Lugano ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"2026011721163085800_ejhf558-bib-0001","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/europace\/eut206","article-title":"2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). 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