{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:05:56Z","timestamp":1792073156348,"version":"4.4.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000145","name":"Alberta Innovates\u2013Health Solutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients presenting to the emergency department (ED) with acute heart failure (AHF) are at an increased risk of morbidity and mortality. The electrocardiogram (ECG) is a routine investigation in patients with AHF used to identify potential causes and\/or complications. It is unclear whether 12-lead ECG characteristics can serve as a prognostic indicator in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with AHF from four hospital EDs were prospectively enrolled into the AHF \u2013 Emergency Management cohort. In addition to baseline data collection, the first available ECG was read in a core laboratory. Clinical outcomes (all-cause mortality and readmission) were recorded and risk models were developed. Of 937 enrolled patients, 816 had a diagnosis of AHF and an available ECG. Median age of the population was 77 [interquartile range (IQR) 67\u201385], 47% were female and median ejection fraction was 45% (IQR 30\u201355). Abnormalities were common, with only 7.5% of patients having a normal ECG. During the median follow-up of 25.7\u2009months, there were 379 (46%) all-cause deaths and 328 (40%) hospital readmissions. Sinus rhythm was associated with better outcomes [hazard ratio (HR) 0.76; 95% confidence interval (CI) 0.62, 0.94], while paced rhythms (HR 1.51, 95% CI 1.11, 2.05), a wide QRS (HR 1.29, 95% CI 1.04, 1.59) and an ECG with any abnormality (HR 1.57, 95% CI 1.01, 2.44) was associated with poorer outcomes. Other individual ECG characteristics were not related to clinical outcomes after risk adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Certain ECG abnormalities are common in patients with AHF and associated with poor outcomes. Used in conjunction with other clinical variables, the ECG may be a useful tool in long-term risk stratifying patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.561","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T04:53:02Z","timestamp":1462423982000},"page":"1032-1040","source":"Crossref","is-referenced-by-count":29,"title":["Insights into the Importance of the Electrocardiogram in Patients with Acute Heart Failure"],"prefix":"10.1093","volume":"18","author":[{"given":"Pishoy","family":"Gouda","sequence":"first","affiliation":[{"name":"Canadian VIGOUR Centre, University of Alberta in Edmonton \u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brown","sequence":"additional","affiliation":[{"name":"Canadian VIGOUR Centre, University of Alberta in Edmonton \u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and School of Public Health, University of Alberta in Edmonton \u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay A.","family":"McAlister","sequence":"additional","affiliation":[{"name":"Canadian VIGOUR Centre, University of Alberta in Edmonton \u00a0","place":["Canada"]},{"name":"Patient Health Outcomes Research and Clinical Effectiveness Unit, University of Alberta in Edmonton \u00a0","place":["Canada"]},{"name":"Division of General Internal Medicine, University of Alberta in Edmonton \u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin A.","family":"Ezekowitz","sequence":"additional","affiliation":[{"name":"Canadian VIGOUR Centre, University of Alberta in Edmonton \u00a0","place":["Canada"]},{"name":"Division of Cardiology, University of Alberta in Edmonton \u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,5,5]]},"reference":[{"key":"2026011721155452700_ejhf561-bib-0001","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/oxfordjournals.eurheartj.a015223","article-title":"The epidemiology of heart failure","volume":"18","author":"Cowie","year":"1997","journal-title":"Eur Heart J"},{"key":"2026011721155452700_ejhf561-bib-0002","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/heart.83.5.596","article-title":"Epidemiology, aetiology, and prognosis of heart failure","volume":"83","author":"McMurray","year":"2000","journal-title":"Heart"},{"key":"2026011721155452700_ejhf561-bib-0003","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1161\/CIRCULATIONAHA.107.696906","article-title":"for the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) Investigators. 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