{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:42:40Z","timestamp":1789458160911,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Mitral regurgitation (MR) is a common finding in patients with heart failure with debatable effects on prognosis. Reduction in MR is one of the mechanisms by which cardiac resynchronization therapy (CRT) exerts its beneficial effects. We investigated the prognostic impact of baseline MR and MR persistence after CRT on outcomes of treated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We prospectively followed 1122 CRT patients (66.4\u2009\u00b1\u200910.3\u2009years, 78% male) who were stratified according to baseline MR severity as having MR\u2212 (degree 0\u20131; n\u2009=\u2009508, 45%) or MR+ (degrees 2\u20133\u20134; n\u2009=\u2009614, 55%). In 916 patients (82%) with MR severity data available at 1-year follow-up, the annual mortality rate was 3.4 and 6.0 per patient-year in the MR\u2212 and MR+ group, respectively, with a 1-year incidence rate ratio (IRR) of 1.76 (P\u2009&amp;lt;\u20090.001). Similar results were observed for cardiovascular mortality (1-year IRR 1.72, P\u2009=\u20090.002). When considering survival according to MR severity after CRT, all-cause and cardiovascular mortality were lower in the improved than in the worsened group (1-year IRR 1.87 and 2.33, respectively; both P\u2009&amp;lt;\u20090.001). Regression analysis showed that absence of MR improvement at follow-up was a significant independent predictor of both all-cause and cardiovascular mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Baseline significant MR and absence of MR improvement after CRT are strongly predictive of less favourable long-term survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.569","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T01:30:11Z","timestamp":1468459811000},"page":"1060-1068","source":"Crossref","is-referenced-by-count":34,"title":["Prognostic Implications of Mitral Regurgitation in Patients after Cardiac Resynchronization Therapy"],"prefix":"10.1093","volume":"18","author":[{"given":"Manlio","family":"Cipriani","sequence":"first","affiliation":[{"name":"Niguarda Ca\u2019 Granda Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Lunati","sequence":"additional","affiliation":[{"name":"Niguarda Ca\u2019 Granda Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Landolina","sequence":"additional","affiliation":[{"name":"Ospedale Maggiore, Crema \u00a0","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Proclemer","sequence":"additional","affiliation":[{"name":"S. Maria della Misericordia Hospital , Udine ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bologna and Azienda Ospedaliera S, Orsola-Malpighi , Bologna ,","place":["Italy"]},{"name":"Cardiology Department, University of Modena and Reggio Emilia, Policlinico di Modena , Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato P.","family":"Ricci","sequence":"additional","affiliation":[{"name":"San Filippo Neri Hospital , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rordorf","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico S. Matteo IRCCS , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Vittoria","family":"Matassini","sequence":"additional","affiliation":[{"name":"Niguarda Ca\u2019 Granda Hospital , Milan ,","place":["Italy"]},{"name":"Universit\u00e0 Politecnica delle Marche , Ancona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Padeletti","sequence":"additional","affiliation":[{"name":"Careggi Hospital , Firenze ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"GVM Care and Research, Citt\u00e0 di Lecce Hospital , Lecce ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Molon","sequence":"additional","affiliation":[{"name":"Ospedale Sacro Cuore , Negrar ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni B.","family":"Perego","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano , San Luca, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Gasparini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Clinico Humanitas , Rozzano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"2026011721155344200_ejhf569-bib-0001","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0002-9149(02)03301-5","article-title":"Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure","volume":"91","author":"Trichon","year":"2003","journal-title":"Am J 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