{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:12:57Z","timestamp":1792026777378,"version":"4.4.0"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing-synthesis\/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.<\/jats:p>","DOI":"10.1002\/ejhf.645","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T01:48:20Z","timestamp":1478224100000},"page":"1307-1320","source":"Crossref","is-referenced-by-count":147,"title":["Global Left Atrial Failure in Heart Failure"],"prefix":"10.1093","volume":"18","author":[{"given":"Filippos","family":"Triposkiadis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Larissa University Hospital , PO Box 1425, 411 10, Larissa ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin\u2014Campus Virchow Klinikum, and Department of Internal Medicine and Cardiology, German Heart Centre, Berlin Centre for Heart Failure , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"Cardiology Division, School of Medicine, Stony Brook University , Stony Brook, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parissis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Athens University Hospital Attikon , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Giamouzis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Larissa University Hospital , PO Box 1425, 411 10, Larissa ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Skoularigis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Larissa University Hospital , PO Box 1425, 411 10, Larissa ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Brutsaert","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology (Building T2), University of Antwerp , Universiteitsplein 1, Antwerp, 2610 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harisios","family":"Boudoulas","sequence":"additional","affiliation":[{"name":"Ohio State University , Columbus, Ohio ,","place":["USA"]},{"name":"Biomedical Research Foundation Academy of Athens, Athens, and Aristotelian University of Thessaloniki , Thessaloniki ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"2026011721164740800_ejhf645-bib-0001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1053\/euhj.1999.2581","article-title":"A clinical appraisal of left atrial 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