{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:58:57Z","timestamp":1768773537925,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The EchoCRT trial was funded by Biotronik and GE Healthcare.","award":["G080067"],"award-info":[{"award-number":["G080067"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>As patients with heart failure (HF) and concomitant diabetes carry a poor prognosis, this post-hoc subgroup analysis aimed to compare the outcomes of patients with and without diabetes randomized in the Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>EchoCRT randomized patients with a QRS duration &amp;lt;130\u2009ms and echocardiographic evidence of left ventricular dyssynchrony to CRT turned on (CRT=ON) vs. off (CRT=OFF) following device implantation. At study entry, 328 patients (40.5%) had diabetes. The primary outcome (all-cause death or first hospitalization for worsening HF) occurred more frequently in patients with than without diabetes (32.6% vs. 23%, P\u2009=\u20090.003). A significant treatment interaction was observed for the primary outcome indicating a higher risk for CRT=ON vs. CRT-OFF in patients without [26.5% vs. 19.8%, hazard ratio (HR) 1.58, 95% confidence interval (CI) 1.08\u20132.31] vs. with diabetes (31.4% vs. 34%; HR 0.86, 95% CI 0.58\u20131.27; P for interaction 0.041). This effect was mainly driven by a lower rate in HF hospitalizations, but was only of borderline significance after multivariate adjustment (P\u2009=\u20090.063). The most pronounced effect was observed in patients with non-ischaemic cardiomyopathy, where a significantly reduced risk of reaching the primary endpoint for CRT=ON vs. CRT-OFF was observed in patients with (HR 0.27, P\u2009=\u20090.003) vs. patients without diabetes (HR 1.79, P\u2009=\u20090.038; P for interaction 0.005). No treatment interaction by diabetes diagnosis was found for mortality endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In EchoCRT, HF patients with a narrow QRS complex and coexisting diabetes demonstrated a signal for less harm caused by CRT compared with patients without diabetes, which was driven by differences in hospitalizations owing to HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.655","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T16:10:25Z","timestamp":1479139825000},"page":"80-87","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Cardiac Resynchronization Therapy in Patients with Diabetes Randomized in EchoCRT"],"prefix":"10.1093","volume":"19","author":[{"given":"Matthias P.","family":"N\u00e4gele","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Heart Centre Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Steffel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Robertson","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics, University of Glasgow , Glasgow ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagmeet P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas J.","family":"Flammer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Centre Zurich , Zurich 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,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Ford","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics, University of Glasgow , Glasgow ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"John","family":"Gorcsan","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , Pittsburgh, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gras","sequence":"additional","affiliation":[{"name":"Nouvelles Cliniques Nantaises , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Krum","sequence":"additional","affiliation":[{"name":"Monash Centre of Cardiovascular Research and Education in Therapeutics , Melbourne, VIC 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