{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:52:51Z","timestamp":1771912371655,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002738","name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Appel d'offre m\u00e9decine aigu\u00eb\u2013 Call Acute Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the interest of brain natriuretic peptide (BNP) for heart failure (HF) diagnosis in very old patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 383 patients aged 80 years or older, hospitalized in geriatrics care for dyspnoea, had a BNP measurement at the acute phase. Independent cardiologists blinded to BNP values classified the patients into cardiac vs. respiratory aetiology according to the European Society of Cardiology guidelines. Mean (SD) age was 88.5 (5.4) years, 66% (n = 254) of patients were women, 62% (n = 238) had cardiac dyspnoea and 38% (n = 145) had respiratory dyspnoea. The BNP levels were significantly higher in the cardiac group (median = 385.5 ng\/L, interquartile range = 174.0\u2013842.0) than in the respiratory group (median = 172.0 ng\/L, interquartile range = 70.8\u2013428.0; P &amp;lt; 0.001). On its own, BNP showed poor discriminative ability [area under the curve (AUC) = 0.68; 95% confidence interval (CI) 0.62\u20130.73] for the diagnostic. In multivariate analysis, BNP remained independently associated with the cardiac aetiology after full-adjustment (odds ratio 1 log increase = 1.87; 95% CI 1.28\u20132.74), but did not improve the discrimination between the cardiac and the respiratory aetiologies (\u0394AUC = 0.013, P = 0.16). In addition, although adding BNP to the other predictive covariates yielded a significant continuous NRI of 57.8% (95% CI 31.2\u201383.5%), the mean changes in individual predicted probabilities were too low (&amp;lt;3%) to be clinically relevant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this population of very old patients with acute dyspnoea, despite being independently associated with the cardiac aetiology, BNP was not useful for better discriminating cardiac vs. respiratory origin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.699","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T20:26:44Z","timestamp":1482784004000},"page":"540-548","source":"Crossref","is-referenced-by-count":32,"title":["Brain Natriuretic Peptide Usefulness in Very Elderly Dyspnoeic Patients: The BED Study"],"prefix":"10.1093","volume":"19","author":[{"given":"Matthieu","family":"Plichart","sequence":"first","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Broca Hospital , Paris ,","place":["France"]},{"name":"EA 4468, Paris Cardiovascular Research Centre, PARCC , Paris ,","place":["France"]},{"name":"University Paris Descartes, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Inserm, UMR-S970, Paris Cardiovascular Research Centre, PARCC , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galdric","family":"Orvo\u00ebn","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Broca Hospital , Paris ,","place":["France"]},{"name":"EA 4468, Paris Cardiovascular Research Centre, PARCC , Paris ,","place":["France"]},{"name":"University Paris Descartes, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Jourdain","sequence":"additional","affiliation":[{"name":"Ren\u00e9 Dubos Hospital, Cardiology Department , Pontoise ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Quinquis","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris, H\u00f4tel Dieu Hospital, Epidemiology and Biostatistics Unit, University Paris Descartes, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00ebl","family":"Coste","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris, H\u00f4tel Dieu Hospital, Epidemiology and Biostatistics Unit, University Paris Descartes, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Escande","sequence":"additional","affiliation":[{"name":"Clinique Vert Coteau, Cardiology Department , Marseille ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Friocourt","sequence":"additional","affiliation":[{"name":"Blois Hospital, Department of Cardiology , Blois ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Paillaud","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital , Cr\u00e9teil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois-Xavier","family":"Chedhomme","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Broca Hospital , Paris ,","place":["France"]},{"name":"EA 4468, Paris Cardiovascular Research Centre, PARCC , Paris ,","place":["France"]},{"name":"University Paris Descartes, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Labour\u00e9e","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Broca Hospital , Paris ,","place":["France"]},{"name":"EA 4468, Paris Cardiovascular Research Centre, PARCC , Paris ,","place":["France"]},{"name":"University Paris Descartes, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mence","family":"Boully","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Broca Hospital , Paris ,","place":["France"]},{"name":"EA 4468, Paris Cardiovascular Research Centre, PARCC , Paris ,","place":["France"]},{"name":"University Paris Descartes, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanase","family":"Benetos","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, University Hospital of Nancy, INSERM U1116, University of Lorraine \u00a0","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Domerego","sequence":"additional","affiliation":[{"name":"Geriatric Hospital \u2018Les Sources\u2019 , Nice ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Komajda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Piti\u00e9-Salp\u00e9tri\u00e8re Hospital, University Pierre et Marie Curie and IHU ICAN , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Hanon","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Broca Hospital , Paris 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