{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:59:05Z","timestamp":1792814345622,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":159,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Dilated cardiomyopathy (DCM) has a monogenic aetiology in up to 40% of patients. Understanding the spectrum of genotype\u2013phenotype associations in DCM is crucial for risk stratification and personalized treatment. We aimed to (i) characterize genotype-specific features, (ii) evaluate whether phenotype-based clustering reflects underlying genotype, and (iii) compare the prognostic value of genotype- versus phenotype-based approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A multicentre cohort of 534 DCM patients with a (likely) pathogenic variant were grouped by genotype (genotype-first approach) and clustered by clinical phenotype (phenotype-first approach). We compared clinical characteristics, identified genotype\u2013phenotype associations, and evaluated outcomes, including all-cause mortality, heart failure hospitalization, heart transplantation, and malignant ventricular arrhythmias. Using the genotype-first approach, significant genotype\u2013phenotype associations were found for 10 genes. FLNC, LMNA, DSP, and PLN variants were linked to arrhythmias. BAG3, TNNT2, DMD, and TTN were associated with increased cardiac volumes and decreased left ventricular ejection fraction (LVEF). Clustering identified four phenotypic clusters: (1) young, moderately reduced LVEF; (2) arrhythmias, moderate reduced LVEF; (3) low LVEF; (4) arrhythmias, low LVEF. There were no clear correlations between phenotypic clusters and genotype. The genotype-first approach showed that LMNA, FLNC, and BAG3 variants had the highest risk for heart failure and arrhythmogenic adverse outcomes. The phenotype-first approach indicated that clusters 3 and 4 were associated with the worst prognosis. Overall, genotype was the strongest predictor of outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with a genetic form of DCM exhibit clinical and genetic heterogeneity. Genotype-based risk stratification is more accurate compared to a phenotype-first approach, highlighting the importance of broad genetic screening among patients with DCM. Additionally, gene-specific risk prediction should become more prominent in current guidelines on management of genetic DCM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.70040","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:03:00Z","timestamp":1757696580000},"page":"3205-3218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Impact of Genotype\u2013Phenotype Associations on Prognosis in Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-6359","authenticated-orcid":false,"given":"Sophie L.V.M.","family":"Stroeks","sequence":"first","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]},{"name":"KU Leuven, Cardiovascular Sciences , Leuven ,","place":["Belgium"]},{"name":"Department of Clinical Genetics, Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]},{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]},{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Muller","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Netherlands Heart Institute , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Paldino","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Mora-Ayestaran","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV , Madrid ,","place":["Spain"]},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIV) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Jason","sequence":"additional","affiliation":[{"name":"CU Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo dal","family":"Ferro","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Pio Loco detto Gava","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV , Madrid ,","place":["Spain"]},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIV) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV , Madrid ,","place":["Spain"]},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIV) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"van den Wijngaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max F.G.H.M.","family":"Venner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurits","family":"Sikking","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Minten","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Nihant","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Graw","sequence":"additional","affiliation":[{"name":"CU Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Medo","sequence":"additional","affiliation":[{"name":"CU Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"de Koning","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]},{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Taylor","sequence":"additional","affiliation":[{"name":"CU Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Peter","family":"van Tintelen","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Genetics, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Mestroni","sequence":"additional","affiliation":[{"name":"CU Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneline S.J.M.","family":"te Riele","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Netherlands Heart Institute , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia-Pavia","sequence":"additional","affiliation":[{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"},{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV , Madrid ,","place":["Spain"]},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIV) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Heymans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]},{"name":"KU Leuven, Cardiovascular Sciences , Leuven ,","place":["Belgium"]},{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Job A.J.","family":"Verdonschot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , Maastricht ,","place":["The Netherlands"]},{"name":"Department of Clinical Genetics, Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]},{"name":"Members of the European Reference Network for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"2026021721511171400_ejhf70040-bib-0001","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrcardio.2013.105","article-title":"Dilated cardiomyopathy: The complexity of a diverse genetic architecture","volume":"10","author":"Hershberger","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"2026021721511171400_ejhf70040-bib-0002","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006832","article-title":"Clinical phenotypes and prognosis of dilated cardiomyopathy caused by truncating variants in the TTN gene","volume":"13","author":"Akhtar","year":"2020","journal-title":"Circ Heart Fail"},{"key":"2026021721511171400_ejhf70040-bib-0003","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1093\/eurheartj\/ehab286","article-title":"Understanding the genetics of adult-onset dilated cardiomyopathy: What a clinician needs to know","volume":"42","author":"Tayal","year":"2021","journal-title":"Eur Heart J"},{"key":"2026021721511171400_ejhf70040-bib-0004","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1002\/ejhf.3446","article-title":"The next era of gene-specific clinical care in patients with dilated cardiomyopathy","volume":"26","author":"Verdonschot","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026021721511171400_ejhf70040-bib-0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ejhf.3516","article-title":"State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases","volume":"27","author":"Van Linthout","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"2026021721511171400_ejhf70040-bib-0006","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"2026021721511171400_ejhf70040-bib-0007","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current diagnostic and treatment strategies for specific dilated cardiomyopathies: A scientific statement from the American Heart Association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"key":"2026021721511171400_ejhf70040-bib-0008","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.jacc.2022.08.804","article-title":"Prognostic prediction of genotype vs phenotype in genetic cardiomyopathies","volume":"80","author":"Paldino","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026021721511171400_ejhf70040-bib-0009","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10050921","article-title":"Diagnosis and risk prediction of dilated cardiomyopathy in the era of big data and genomics","volume":"10","author":"Sammani","year":"2021","journal-title":"J Clin Med"},{"key":"2026021721511171400_ejhf70040-bib-0010","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jacbts.2022.10.010","article-title":"Clustering of cardiac transcriptome profiles reveals unique: Subgroups of dilated cardiomyopathy patients","volume":"8","author":"Verdonschot","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"2026021721511171400_ejhf70040-bib-0011","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.jacc.2022.03.375","article-title":"Precision phenotyping of dilated cardiomyopathy using multidimensional data","volume":"79","author":"Tayal","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026021721511171400_ejhf70040-bib-0012","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/eurheartj\/ehaa841","article-title":"Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences","volume":"42","author":"Verdonschot","year":"2021","journal-title":"Eur Heart J"},{"key":"2026021721511171400_ejhf70040-bib-0013","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s12471-019-1288-4","article-title":"UNRAVEL: Big data analytics research data platform to improve care of patients with cardiomyopathies using routine electronic health records and standardised biobanking","volume":"27","author":"Sammani","year":"2019","journal-title":"Neth Heart J"},{"key":"2026021721511171400_ejhf70040-bib-0014","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"2026021721511171400_ejhf70040-bib-0015","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2026021721511171400_ejhf70040-bib-0016","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11634-014-0195-1","article-title":"A principal component method to impute missing values for mixed data","volume":"10","author":"Audigier","year":"2013","journal-title":"Adv Data Anal Classif"},{"key":"2026021721511171400_ejhf70040-bib-0017","volume-title":"Principal component methods \u2013 hierarchical clustering \u2013 partitional clustering: Why would we need to choose for visualizing data?","author":"Husson","year":"2010"},{"key":"2026021721511171400_ejhf70040-bib-0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v061.i06","article-title":"NbClust: An R package for determining the relevant number of clusters in a data set","volume":"61","author":"Charrad","year":"2014","journal-title":"J Stat Softw"},{"key":"2026021721511171400_ejhf70040-bib-0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v025.i01","article-title":"FactoMineR: An R package for multivariate analysis","volume":"25","author":"L\u00ea","year":"2008","journal-title":"J Stat Softw"},{"key":"2026021721511171400_ejhf70040-bib-0020","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1093\/eurheartj\/ehab294","article-title":"Prediction of ventricular arrhythmia in phospholamban p.Arg14del mutation carriers \u2013 reaching the frontiers of individual risk prediction","volume":"42","author":"Verstraelen","year":"2021","journal-title":"Eur Heart J"},{"key":"2026021721511171400_ejhf70040-bib-0021","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/CIRCULATIONAHA.118.039410","article-title":"Development and validation of a new risk prediction score for life-threatening ventricular tachyarrhythmias in laminopathies","volume":"140","author":"Wahbi","year":"2019","journal-title":"Circulation"},{"key":"2026021721511171400_ejhf70040-bib-0022","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1161\/CIRCRESAHA.122.319835","article-title":"Arrhythmias as presentation of genetic cardiomyopathy","volume":"130","author":"Lukas Laws","year":"2022","journal-title":"Circ Res"},{"key":"2026021721511171400_ejhf70040-bib-0023","doi-asserted-by":"crossref","first-page":"797","DOI":"10.4070\/kcj.2021.0154","article-title":"Genetics of cardiomyopathy: Clinical and mechanistic implications for heart failure","volume":"51","author":"Kim","year":"2021","journal-title":"Korean Circ J"},{"key":"2026021721511171400_ejhf70040-bib-0024","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/jamacardio.2024.5543","article-title":"Arrhythmic risk stratification of carriers of filamin C truncating variants","volume":"10","author":"Gigli","year":"2025","journal-title":"JAMA Cardiol"},{"key":"2026021721511171400_ejhf70040-bib-0025","doi-asserted-by":"crossref","DOI":"10.1007\/s11886-024-02168-6","article-title":"Hot phases cardiomyopathy: Pathophysiology, diagnostic challenges, and emerging therapies","volume":"27","author":"Bassetto","year":"2025","journal-title":"Curr Cardiol Rep"},{"key":"2026021721511171400_ejhf70040-bib-0026","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.jacep.2023.04.020","article-title":"Recurrent myocarditis in patients with desmosomal pathogenic variants: Is self antigen presentation the link?","volume":"9","author":"Mayfield","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"2026021721511171400_ejhf70040-bib-0027","doi-asserted-by":"crossref","DOI":"10.3390\/biom12091324","article-title":"Myocarditis-like episodes in patients with arrhythmogenic cardiomyopathy: A systematic review on the so-called hot-phase of the disease","volume":"12","author":"Bariani","year":"2022","journal-title":"Biomolecules"},{"key":"2026021721511171400_ejhf70040-bib-0028","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jacep.2017.12.003","article-title":"Filamin C truncation mutations are associated with arrhythmogenic dilated cardiomyopathy and changes in the cell-cell adhesion structures","volume":"4","author":"Begay","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"2026021721511171400_ejhf70040-bib-0029","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.hrthm.2021.09.029","article-title":"Filamin-C variant-associated cardiomyopathy: A pooled analysis of individual patient data to evaluate the clinical profile and risk of sudden cardiac death","volume":"19","author":"Celeghin","year":"2022","journal-title":"Heart Rhythm"},{"key":"2026021721511171400_ejhf70040-bib-0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijcard.2019.09.048","article-title":"Filamin C variants are associated with a distinctive clinical and immunohistochemical arrhythmogenic cardiomyopathy phenotype","volume":"307","author":"Hall","year":"2020","journal-title":"Int J Cardiol"},{"key":"2026021721511171400_ejhf70040-bib-0031","first-page":"2968","article-title":"A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers","volume":"45","author":"Carrick","year":"2024","journal-title":"Eur Heart J"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/27\/12\/3205\/66836678\/eurjhf_27_12_3205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/27\/12\/3205\/66836678\/eurjhf_27_12_3205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:51:20Z","timestamp":1771383080000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/27\/12\/3205\/8470606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,9,12]]},"published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.70040","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"2025-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}