{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:34:14Z","timestamp":1792258454751,"version":"4.4.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":3313,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The prognosis of patients hospitalized for worsening heart failure (HF) is well described, but not that of patients managed solely in non-acute settings such as primary care or secondary outpatient care. We assessed the distribution of HF across levels of healthcare, and assessed the prognostic differences for patients with HF either recorded in primary care (including secondary outpatient care) (PC), hospital admissions alone, or known in both contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This study was part of the CALIBER programme, which comprises linked data from primary care, hospital admissions, and death certificates for 2.1 million inhabitants of England. We identified 89 554 patients with newly recorded HF, of whom 23 547 (26%) were recorded in PC but never hospitalized, 30 629 (34%) in hospital admissions but not known in PC, 23 681 (27%) in both, and 11 697 (13%) in death certificates only. The highest prescription rates of ACE inhibitors, beta-blockers, and mineralocorticoid receptor antagonists was found in patients known in both contexts. The respective 5-year survival in the first three groups was 43.9% [95% confidence interval (CI) 43.2\u201344.6%], 21.7% (95% CI 21.1\u201322.2%), and 39.8% (95% CI 39.2\u201340.5%), compared with 88.1% (95% CI 87.9\u201388.3%) in the age- and sex-matched general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the general population, one in four patients with HF will not be hospitalized for worsening HF within a median follow-up of 1.7\u2009years, yet they still have a poor 5-year prognosis. Patients admitted to hospital with worsening HF but not known with HF in primary care have the worst prognosis and management. Mitigating the prognostic burden of HF requires greater consistency across primary and secondary care in the identification, profiling, and treatment of patients.<\/jats:p>\n                    <jats:p>Trial registration: NCT02551016<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.709","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T11:29:26Z","timestamp":1482578966000},"page":"1119-1127","source":"Crossref","is-referenced-by-count":128,"title":["Prognostic Burden of Heart Failure Recorded in Primary Care, Acute Hospital Admissions, or Both: A Population-Based Linked Electronic Health Record Cohort Study in 2.1 Million People"],"prefix":"10.1093","volume":"19","author":[{"given":"Stefan","family":"Koudstaal","sequence":"first","affiliation":[{"name":"Farr Institute of Health Informatics Research , London ,","place":["UK"]},{"name":"UCL Institute of Health Informatics, University College London , London ,","place":["UK"]},{"name":"Department of Cardiology, University Medical Centre Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Pujades-Rodriguez","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research , London ,","place":["UK"]},{"name":"UCL Institute of Health Informatics, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Denaxas","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research , London ,","place":["UK"]},{"name":"UCL Institute of Health Informatics, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.I.H.","family":"Gho","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Centre Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop D.","family":"Shah","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research , London ,","place":["UK"]},{"name":"UCL Institute of Health Informatics, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yu","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research , London ,","place":["UK"]},{"name":"UCL Institute of Health Informatics, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyaz S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research , London ,","place":["UK"]},{"name":"UCL Institute of Health Informatics, University College London , London ,","place":["UK"]},{"name":"UCL Institute of Cardiovascular Sciences, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris P.","family":"Gale","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno W.","family":"Hoes","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Cleland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National Heart & Lung Institute, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert W.","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research , 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