{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:28:55Z","timestamp":1791829735332,"version":"4.3.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"European Union Regional Development Funds"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Cardiovasculares"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Economy and Competitiveness"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyse the incidence, risk factors and clinical outcomes of late graft failure after heart transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We conducted an observational, single-centre study based on 547 patients who underwent cardiac transplantation from 1991 to 2014 and who survived the in-hospital postoperative period. Late graft failure was defined as the first hospitalization due to this condition after discharge. Over a mean follow-up of 8.4\u2009\u00b1\u20096 years, 178 (32.5%) patients were hospitalized due to late graft failure [incidence rate: 3.6 cases per 100 patient-years, 95% confidence interval (CI) 3.1\u20134.2]. Pre-transplant diabetes, higher pre-transplant transpulmonary pressure gradient and lower donor\u2013recipient weight ratio were independently associated with higher risk of graft failure. Cardiac allograft vasculopathy, cellular rejection grade \u22651R, and antibody-mediated rejection grade \u22651 were detected in 50.6%, 44.9% and 19.2% patients, respectively, admitted due to graft failure. Left ventricular ejection fraction was \u226550% in 60.1% of these patients. Re-transplant free survival 1, 5, 10 and 15 years after the diagnosis of late graft failure was 72.2%, 38.4%, 18.4%, and 7.5%, respectively; the incidence rate of re-hospitalization due to decompensated heart failure was 40.9 episodes per 100 patient-years (95% CI 36.6\u201346.1). The need for inotropes, the presence of cardiac allograft vasculopathy, higher creatinine serum levels, lower ejection fraction and lower sodium serum levels were independent predictors of worse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Late graft failure is frequent after heart transplantation, as it is associated with poor outcomes. Rejection and cardiac allograft vasculopathy are the most frequent underlying causes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.886","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T02:02:45Z","timestamp":1496628165000},"page":"385-394","source":"Crossref","is-referenced-by-count":61,"title":["Late Graft Failure in Heart Transplant Recipients: Incidence, Risk Factors and Clinical Outcomes"],"prefix":"10.1093","volume":"20","author":[{"given":"\u00c1ngela","family":"L\u00f3pez-Sainz","sequence":"first","affiliation":[{"name":"Servicio de Cardiolog\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Barge-Caballero","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Barge-Caballero","sequence":"additional","affiliation":[{"name":"Servicio de 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de Enfermedades Cardiovasculares (CIBERCV) , La Coruna ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Herrera-Nore\u00f1a","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Cardiaca; Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC), Servicio Galego de Sa\u00fade (SERGAS), Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Universidad de A Coru\u00f1a (UDC), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , La Coruna ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J.","family":"Cuenca-Castillo","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Cardiaca; Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC), Servicio Galego de Sa\u00fade (SERGAS), Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Universidad de A Coru\u00f1a (UDC), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , La Coruna ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"V\u00e1zquez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"Crespo-Leiro","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"2026011721221644900_ejhf886-bib-0001","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.healun.2016.08.017","article-title":"The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Heart Transplantation Report\u20132016; Focus Theme: primary diagnostic indications for 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