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The AdaptResponse study is a prospective, randomized, controlled, single-blinded, multicentre, clinical trial (ClinicalTrials.gov Identifier: NCT02205359), conducted at up to 200 centres worldwide. Following enrolment and baseline assessment, eligible subjects will be implanted with a CRT system containing the AdaptivCRT algorithm, and randomized in a 1:1 fashion to either a treatment (\u2018AdaptivCRT\u2019) or control (\u2018Conventional CRT\u2019) group. The study is designed to observe a primary endpoint in 1100 patients (\u2018event-driven\u2019) and approximately 3000 patients will be randomized. The primary endpoint is the composite of all-cause mortality and intervention for HF decompensation; secondary endpoints include all-cause mortality, intervention for HF decompensation, clinical composite score (CCS) at 6 months, atrial fibrillation, quality of life measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ), health outcome measured by the EQ-5D instrument, all-cause readmission after a HF admission, and cost-effectiveness. The AdaptResponse clinical trial is powered to assess clinical endpoints and is expected to provide definitive evidence on the incremental utility of AdaptivCRT-enhanced CRT systems.<\/jats:p>","DOI":"10.1002\/ejhf.895","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T09:15:13Z","timestamp":1500023713000},"page":"950-957","source":"Crossref","is-referenced-by-count":35,"title":["Rationale and Design of the Adaptresponse Trial: A Prospective Randomized Study of Cardiac Resynchronization Therapy with Preferential Adaptive Left Ventricular-Only Pacing"],"prefix":"10.1093","volume":"19","author":[{"given":"Gerasimos","family":"Filippatos","sequence":"first","affiliation":[{"name":"National and Kapodistrian University of Athens, School of Medicine , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Birnie","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Gold","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina , Charleston, SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Gerritse","sequence":"additional","affiliation":[{"name":"Medtronic plc, Bakken Research Center (BRC) , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Hersi","sequence":"additional","affiliation":[{"name":"King Saud University, College of Medicine, Department of Cardiac Sciences , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Medtronic plc, Bakken Research Center (BRC) , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Kusano","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Centre , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Leclercq","sequence":"additional","affiliation":[{"name":"University Hospital Rennes, University of Rennes I and CIC-IT 804 , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Mullens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Genk ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Wilkoff","sequence":"additional","affiliation":[{"name":"Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"2026011721190790700_ejhf895-bib-0001","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","article-title":"2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). 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