{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:03:25Z","timestamp":1790237005457,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung"},{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung e.V","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Abbott Vascular, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of the present study was to assess the safety and efficacy of percutaneous mitral valve repair using the MitraClip\u2122 device in patients with severely reduced systolic left ventricular (LV) function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Among 777 MitraClip\u2122 implantations included in the German mitral valve registry, we identified 256 patients suffering from severely reduced LV function [ejection fraction (EF) &amp;lt;30%] in whom successful percutaneous mitral valve repair was performed. Procedural safety, efficacy, and 1-year outcome was compared with 241 patients with preserved LV function (EF &amp;gt;50%) and 280 patients presenting with an EF 30\u201350% prior to MitraClip\u2122 therapy. High procedural success rates, low periprocedural complication rates, and low residual mitral regurgitation grades at discharge were achieved throughout all groups. In-hospital mortality was low and comparable in all groups. After 1 year, mortality rates were 24.2% (EF &amp;lt;30%), 17.3% (EF 30\u201350%), and 18.9% (EF &amp;gt;50%). Major adverse cardiac or cardiovascular event rates were 29.7% (EF &amp;lt;30%), 24.4% (EF 30\u201350%), and 23.5% (EF &amp;gt;50%). Procedural failure was the main predictor for mortality in EF &amp;lt;30% patients (hazard ratio 10.38; 95% CI 3.71\u201329.02). Improved clinical symptoms were observed in the majority of patients in all groups. Thus, 69.5% of EF &amp;lt;30% patients improved by one or more New York Heart Association functional class. Compared with patients with preserved LV function, this is a significantly larger proportion (EF &amp;gt;50%: 56.8%; P &amp;lt; 0.05). Moreover, quality of life, being very poor at baseline, improved distinctively in severe heart failure patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with severely reduced systolic LV function undergoing MitraClip\u2122 therapy, procedural safety, efficacy, and clinical improvement after 1 year are comparable to patients with preserved LV function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.910","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T03:18:52Z","timestamp":1503026332000},"page":"598-608","source":"Crossref","is-referenced-by-count":67,"title":["Safety and Efficacy of Mitraclip\u2122 Therapy in Patients with Severely Impaired Left Ventricular Ejection Fraction: Results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry"],"prefix":"10.1093","volume":"20","author":[{"given":"Nicolas A.","family":"Geis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, University of Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Puls","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University of G\u00f6ttingen , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[{"name":"Heart Centre Eppendorf, University of Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S.","family":"Zuern","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Cardiovascular Medicine, University of T\u00fcbingen , T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Franke","sequence":"additional","affiliation":[{"name":"Cardiovascular Centre St. Katharinen Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schueler","sequence":"additional","affiliation":[{"name":"Heart Centre, University of Bonn , Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph S.","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Medical Clinic II, University of Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boekstegers","sequence":"additional","affiliation":[{"name":"Helios Heart Centre , Siegburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoufik","family":"Ouarrak","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung , Ludwigshafen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Zahn","sequence":"additional","affiliation":[{"name":"Heart Centre Ludwigshafen , Ludwigshafen am Rhein ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vivantes Klinikum im Friedrichshain and Vivantes Klinikum Am Urban, Berlin, Germany, and Rostock University Medical Centre , Rostock ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung , Ludwigshafen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University of Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffi","family":"Bekeredjian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University of Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"2026011721225192100_ejhf910-bib-0001","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.jacc.2005.07.065","article-title":"Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I Clinical Trial","volume":"46","author":"Feldman","year":"2005","journal-title":"J Am Coll 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