{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:51:13Z","timestamp":1791363073731,"version":"4.3.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Department of Emergence Medicine and Services of Helsinki University Hospital"},{"DOI":"10.13039\/100007634","name":"Ida Montin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007083","name":"Orion Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010133","name":"Aarne Koskelo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008484","name":"Paavo Nurmi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008484","id-type":"DOI","asserted-by":"publisher"}]},{"name":"W.E. Stockmann Foundation"},{"name":"Finnish Cardiac Foundation"},{"name":"university-level health research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the incidence, haemodynamic alterations and 90-day mortality of acute kidney injury (AKI) in patients with cardiogenic shock. We assessed the utility of creatinine, urine output (UO) and cystatin C (CysC) definitions of AKI in prognostication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Cardiogenic shock patients with serial plasma samples (n = 154) from the prospective multicenter CardShock study were included in the analysis. Acute kidney injury was defined and staged according to the KDIGO criteria by creatinine (AKIcrea) and\/or UO (AKIUO). CysC-based AKI (AKICysC) was defined similarly to AKIcrea. Changes in haemodynamic parameters were assessed over time from baseline until 96 h. Mean age of the study population was 66 \u00b1 12 years and 74% were men. Median baseline creatinine was 1.12 [interquartile range (IQR) 0.87\u20131.54] mg\/dL and CysC 1.19 (IQR 0.90\u20131.69) mg\/L. The 90-day mortality was 38%. The incidences for AKI were: AKIcrea 31%, AKIUO 50%, and AKICysc 33%. AKIcrea [odds ratio (OR) 12.2, 95% confidence interval (CI) 4.1\u201336.0] and AKICysC (OR 2.5, 95% CI 1.1\u20136.1), but not AKIUO, were independent predictors of mortality. However, a stricter UO cut-off of &amp;lt;0.3 mL\/kg\/h for 6 h was independently associated with 90-day mortality (OR 3.6, 95% CI 1.4\u20139.3). Development of AKI was associated with persistently elevated central venous pressure and decreased cardiac index and mean arterial pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute kidney injury is frequent in patients with cardiogenic shock and especially AKIcrea predicts poor outcome. The KDIGO UO criterion seems, however, rather liberal and a stricter AKI definition of UO &amp;lt;0.3 mL\/kg\/h for at least 6 h seems more useful for mortality risk prediction. Haemodynamic alterations reflecting venous congestion and hypoperfusion were associated with AKI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.958","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T05:22:57Z","timestamp":1506489777000},"page":"572-581","source":"Crossref","is-referenced-by-count":115,"title":["Acute Kidney Injury in Cardiogenic Shock: Definitions, Incidence, Haemodynamic Alterations, and Mortality"],"prefix":"10.1093","volume":"20","author":[{"given":"Tuukka","family":"Tarvasm\u00e4ki","sequence":"first","affiliation":[{"name":"Emergency Medicine, University of Helsinki, and Department of Emergency Medicine and Services, Helsinki University Hospital , Helsinki ,","place":["Finland"]},{"name":"Heart and Lung Center, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Haapio","sequence":"additional","affiliation":[{"name":"Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"INSERM U942, H\u00f4pital Lariboisi\u00e8re, APHP and University Paris Diderot , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sionis","sequence":"additional","affiliation":[{"name":"Intensive Cardiac Care Unit, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute IIB Sant Pau , Universitat de Barcelona, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Silva-Cardoso","sequence":"additional","affiliation":[{"name":"CINTESIS - Center for Health Technology and Services Research, Department of Cardiology, Faculty of Medicine, University of Porto, S\u00e3o Jo\u00e3o Medical Center , Porto ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli","family":"Tolppanen","sequence":"additional","affiliation":[{"name":"Heart and Lung Center, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]},{"name":"Heart Center, P\u00e4ij\u00e4t-H\u00e4me Central Hospital , Lahti ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias Greve","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Intensive Cardiac Care Unit, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Pulkki","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, University of Eastern Finland and Eastern Finland Laboratory Centre , Kuopio ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parissis","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Attikon University Hospital , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veli-Pekka","family":"Harjola","sequence":"additional","affiliation":[{"name":"Emergency Medicine, University of Helsinki, and Department of Emergency Medicine and Services, Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lassus","sequence":"additional","affiliation":[{"name":"Heart and Lung Center, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"2026011721222800200_ejhf958-bib-0001","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneph.2013.282","article-title":"Acute kidney injury\u2014epidemiology, outcomes and economics","volume":"10","author":"Rewa","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"2026011721222800200_ejhf958-bib-0002","doi-asserted-by":"crossref","first-page":"R204","DOI":"10.1186\/cc2872","article-title":"Acute renal failure\u2014definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"8","author":"Bellomo","year":"2004","journal-title":"Crit Care"},{"key":"2026011721222800200_ejhf958-bib-0003","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/cc5713","article-title":"Acute Kidney Injury Network. 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