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Skin\u2010sensitizing activity was also detected in calf urine after uptake of colostrum. Evidence is presented for an anamnestic response, suggesting the existence of an immunological memory for the formation of skin\u2010sensitizing antibodies. The homocytotropic antibody was shown to be heat labile and sensitive to treatment with 2\u2010mercaptoethanol. Time course studies revealed that homocytotropic antibodies persist in calf skin for at least 8 weeks.<\/jats:p><jats:p>The immunoglobulin class associated with homocytotropic activity was enriched from appropriate antisera by salt precipitation, DEAE\u2010cellulose chromatography and gel filtration on Sephadex G\u2010200 columns. The final preparation was still capable of sensitizing calf skin for positive PCA reactions using a minimum dose of 0.009 \u03bcg N. The homocytotropic activity of the vinal fraction could not be removed by antibodies specific for the IgG class, but was completely blocked by antibodies against the fraction enriched in homocytotropic activity. The immunoglobulin class associated with skin\u2010sensitizing activity possesses antigenic determinants which are lacking in \u03bc\u2010, \u03b1\u2010, and \u03b3\u2010chains. The results indicate that the homocytotropic activity in the bovine species is associated with a unique immunoglobulin class analogous to human IgE.<\/jats:p>","DOI":"10.1002\/eji.1830010407","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T21:45:15Z","timestamp":1172612715000},"page":"249-257","source":"Crossref","is-referenced-by-count":38,"title":["Detection of homocytotropic antibody associated with a unique immunoglobulin class in the bovine species"],"prefix":"10.1002","volume":"1","author":[{"given":"D. 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