{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T03:58:59Z","timestamp":1700711939012},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":12738,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1971,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunogenicity of azobenzenearsonate\u2010N\u2010acetyl\u2010<jats:sc>L<\/jats:sc>\u2010tyrosine (ABA\u2010tyrosine) has been confirmed. This low\u2010molecular weight conjugate, in a 50 \u03bcg dose, in complete Freund's adjuvant, regularly induces an apparently pure state of delayed hypersensitivity in guinea pigs. Binding of ABA\u2010tyrosine to proteins seems to be very small.<\/jats:p><jats:p>In detecting delayed hypersensitivity <jats:italic>in vivo<\/jats:italic>, ABA\u2010tyrosine appears much less efficient than a protein conjugate (ABA\u2010guinea pig serum albumin). With <jats:italic>in vitro<\/jats:italic> systems (macrophage migration and lymphocyte transformation) ABA\u2010tyrosine is, on the other hand, as active as the protein conjugate.<\/jats:p><jats:p>Experiments conducted with labeled antigens injected intradermally have shown that ABA\u2010tyrosine was cleared from the skin far more rapidly than the protein conjugate. This fact probably accounts for its weak activity in detecting delayed hypersensitivity <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830010408","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T21:45:15Z","timestamp":1172612715000},"page":"257-262","source":"Crossref","is-referenced-by-count":33,"title":["Delayed hypersensitivity to azobenzenearsonate\u2010N\u2010acetyl\u2010L\u2010tyrosine. <i>In vivo<\/i> and <i>in vitro<\/i> study"],"prefix":"10.1002","volume":"1","author":[{"given":"C.","family":"Nauciel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Raynaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.5.1023"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.5.1037"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00884a028"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3700.1177"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.123.2.229"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/S0021-9258(18)69915-6","volume":"234","author":"Tabachnick M.","year":"1959","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.131.3.571"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0021-9258(18)69477-3","volume":"235","author":"Tabachnick M.","year":"1960","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27841"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.4049\/jimmunol.102.4.852","volume":"102","author":"Ferraresi R. W.","year":"1969","journal-title":"J. Immunol."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000228473"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.6.1451"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.4049\/jimmunol.101.4.764","volume":"101","author":"Stulbarg M.","year":"1968","journal-title":"J. Immunol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.130.5.1123"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.130.5.1031"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4049\/jimmunol.103.6.1395","volume":"103","author":"Eisen A. H.","year":"1969","journal-title":"J. Immunol."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830010408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830010408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T16:40:54Z","timestamp":1698943254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830010408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,1]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1971,1]]}},"alternative-id":["10.1002\/eji.1830010408"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830010408","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,1]]}}}