{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:25:54Z","timestamp":1698971154084},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":12738,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1971,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By incubation with human plasma at 37\u00b0C zymosan is coated with factors forming a complex which liberates anaphylatoxin from rat anaphylatoxinogen. This complex is formel equally well in plasma which has been preabsorbed with zymosan at 0\u00b0C. In contrast to fresh plasma, preabsorbed plasma did not contain detectable antibodies to zymosan. Furthermore, precoating of zymosan with rabbit anti\u2010zymosan antibody did not increase its capability to fix anaphylatoxin\u2010forming factors from preabsorbed human plasma.<\/jats:p><jats:p>Anaphylatoxin formation in rat plasma by incubation with zymosan or Sephadex proceeded equally well regardless of whether the respective antibodies had been eliminated by preabsorption or not. Glycogen proved to be an effective contact agent, inducing anaphylatoxin formation in rat plasma which is unlikely to contain anti\u2010glycogen antibodies.<\/jats:p><jats:p>The findings suggest that natural antibodies to the mentioned polysaccharides are not involved in anaphylatoxin formation induced by contact with plasma. This makes it unlikely that the anaphylatoxin\u2010forming system fixed on zymosan, etc. is represented simply by the complement complex C1423.<\/jats:p><jats:p>Sheep red blood cells can be coated with anaphylatoxin\u2010forming serum factors only when previously loaded with amboceptor.<\/jats:p><jats:p>This suggests that two different pathways of anaphylatoxin formation exist: one is by use of the classical complement reaction, operating when e.g. erythrocyte\u2010antibody complexes are incubated with serum; the other pathway is involved when polysaccarides are used for induction of anaphylatoxin liberation.<\/jats:p>","DOI":"10.1002\/eji.1830010415","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T21:45:15Z","timestamp":1172612715000},"page":"290-295","source":"Crossref","is-referenced-by-count":6,"title":["Anaphylatoxin formation by contact activation of plasma. I. 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