{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:24:18Z","timestamp":1776727458459,"version":"3.51.2"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":12361,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1972,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It could be demonstrated that besides classical anaphylatoxin another stable peptide is formed <jats:italic>in vitro<\/jats:italic> by the contact reaction of mammalian serum with hydrophilic, insoluble substances of high molecular weight, <jats:italic>e.g.<\/jats:italic> dextran, yeast or preformed immune complexes.<\/jats:p><jats:p>This newly detected peptide, called tentatively \u201ccocytotaxin\u201d has been separated from classical anaphylatoxin. It was crystallized in a molecular homogenous state. The basic peptide has a molecular weight of 8500, as determined by gel chromatography, and consists of one peptide unit. Though cocytotaxin is similar in its physicochemical behavior to classical anaphylatoxin, it displays no anaphylatoxin activity. Furthermore, cocytotaxin alone elicites no significant chemotactic activity for neutrophil leucocytes.<\/jats:p>","DOI":"10.1002\/eji.1830020116","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T21:36:53Z","timestamp":1172612213000},"page":"84-89","source":"Crossref","is-referenced-by-count":17,"title":["Chemistry and biology of the anaphylatoxin related serum peptide system. II. Purification, crystallization and properties of cocytotaxin, a basic peptide from rat serum"],"prefix":"10.1002","volume":"2","author":[{"given":"J. H.","family":"Wissler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"207","volume-title":"Cellular and Humoral Mechanisms in Anaphylaxis and Allergy","author":"Webster M. E.","year":"1969"},{"key":"e_1_2_1_3_2","first-page":"215","volume-title":"Cellular and Humoral Mechanisms in Anaphylaxis and Allergy","author":"Movat H. Z.","year":"1969"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.38.070169.002133"},{"key":"e_1_2_1_5_2","first-page":"481","volume-title":"Handbuch der Experimentellen Pharmakologie","author":"Giertz H.","year":"1966"},{"key":"e_1_2_1_6_2","first-page":"260","volume-title":"Cellular and Humoral Mechanisms in Anaphylaxis and Allergy","author":"Vogt W.","year":"1969"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830020115"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01897600"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830020117"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02154281"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0910222"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0960595"},{"key":"e_1_2_1_13_2","unstructured":"Wissler J. H. Stecher V. J. andSorkin E. submitted."},{"key":"e_1_2_1_14_2","first-page":"384","volume":"310","author":"Warburg O.","year":"1941","journal-title":"Biochem. Z."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000230652"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830020116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830020116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T05:30:03Z","timestamp":1698903003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830020116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,2]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,2]]}},"alternative-id":["10.1002\/eji.1830020116"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830020116","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,2]]}}}