{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:19:10Z","timestamp":1756995550192},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":12240,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1972,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>in vitro<\/jats:italic> binding of anti\u2010HL\u2010A antibodies to the membrane of human lymphocytes induces important changes in the distribution of HL\u2010A antigens on the cell surface. Following either direct or indirect immunofluorescence staining at 0 \u00b0C, cell\u2010bound anti\u2010HL\u2010A antibodies are dispersed all over the cell surface. When the washed, stained lymphocytes are warmed and incubated at 37 \u00b0C, fluorescent antibodies cluster progressively at the cell surface. They form large spots of fluorescence, and sometimes single caps at one pole of the cell, outside which HL\u2010A antigens are no longer detectable, but other antigens can still be found. Similar findings were made in electron microscopy, following indirect labeling of HL\u2010A antigens on human lymphocytes, with ferritin or plant virus as the markers.<\/jats:p><jats:p>With the indirect immunofluorescence technique, anti\u2010human thymocyte antibodies and anti\u2010mouse H\u20102 antibodies were found to induce a similar redistribution of the corresponding antigens.<\/jats:p><jats:p>The mechanism and the interpretation of this displacement of surface antigens by antibodies are still unclear and are discussed in terms of membrane structure and immunological significance.<\/jats:p>","DOI":"10.1002\/eji.1830020311","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T21:36:43Z","timestamp":1172612203000},"page":"249-257","source":"Crossref","is-referenced-by-count":109,"title":["Antibody\u2010induced redistribution of HL\u2010A antigens at the cell surface"],"prefix":"10.1002","volume":"2","author":[{"given":"F. 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