{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:25:49Z","timestamp":1698971149288},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":12038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1972,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice were immunized either with lipopolysaccharides (LPS) or with the respective lipid A components. After four days an increase in the number of direct plaque\u2010forming cells with complement\u2010dependent antibody against sheep red cells was seen. Cross\u2010reactions were observed with red cells of cattle, goats, horses and rabbits. All LPS investigated, of <jats:italic>Shigella<\/jats:italic>, <jats:italic>Escherichia coli<\/jats:italic>, and S and R form <jats:italic>Salmonella<\/jats:italic>, as well as the lipid A component evoked this immune response. We therefore conclude that all enterobacterial LPS induce an antibody which cross\u2010reacts with SRC and that the lipid A component is responsible for this reaction. Evidence is presented that these effects, such as toxicity, fever, pyrogen tolerance, leucopenia\/leucocytosis, nonspecific immunity, and tumor inhibition are mediated by lipid A\u2010induced antibodies.<\/jats:p>","DOI":"10.1002\/eji.1830020610","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T22:06:46Z","timestamp":1172614006000},"page":"517-522","source":"Crossref","is-referenced-by-count":12,"title":["The lipid A immunity system. I. Induction of heterophile antibodies by enterobacterial lipopolysaccharides and their lipid A component"],"prefix":"10.1002","volume":"2","author":[{"given":"W.\u2010R.","family":"Rank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dipauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Fl\u00fcgge\u2010Rank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"105","volume-title":"Comprehensive Biochemistry","author":"L\u00fcderitz O.","year":"1968"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19540661312"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1515\/znb-1962-0907","volume":"17","author":"Brittinger G.","year":"1962","journal-title":"Z. Naturforsch."},{"key":"e_1_2_1_5_2","first-page":"385","volume":"118","author":"Farr R. S.","year":"1954","journal-title":"Anat. Rec."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.101.4.421"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.113.3.559"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3680.200"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-126-32479"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4049\/jimmunol.99.1.61","volume":"99","author":"Hege J. S.","year":"1967","journal-title":"J. Immunol."},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/jb.92.4.820-827.1966","volume":"92","author":"Friedman H.","year":"1966","journal-title":"J. Bacteriol."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-119-30276"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-121-31012"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02137991"},{"key":"e_1_2_1_15_2","first-page":"324","volume":"35","author":"Finger H.","year":"1970","journal-title":"Pathol. Microbiol."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-125-32152"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-125-32346"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1128\/jb.95.2.286-290.1968","volume":"95","author":"Freedman H. H.","year":"1968","journal-title":"J. Bacteriol."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-131-34111"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb52385.x"},{"key":"e_1_2_1_21_2","first-page":"323","volume-title":"Procedures in Nucleic Acid Research","author":"Zillig W.","year":"1966"},{"key":"e_1_2_1_22_2","first-page":"83","volume-title":"Methods in Carbohydrate Chemistry","author":"Westphal O.","year":"1965"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1967.tb00066.x"},{"key":"e_1_2_1_24_2","first-page":"246","volume-title":"Methods in Immunology","author":"Campbell D. H.","year":"1964"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/br.30.1.192-255.1966","volume":"30","author":"L\u00fcderitz O.","year":"1966","journal-title":"Bacteriol. Rev."},{"key":"e_1_2_1_26_2","first-page":"69","volume":"174","author":"Westphal O.","year":"1969","journal-title":"Colloquium Int. C. N. R. S., Paris"},{"key":"e_1_2_1_27_2","unstructured":"Rank W.\u2010R. Dissertation Universit\u00e4t M\u00fcnchen1969."},{"key":"e_1_2_1_28_2","first-page":"222","volume":"49","author":"Rank W.\u2010R.","year":"1969","journal-title":"Behringwerk\u2010Mitteilungen"},{"key":"e_1_2_1_29_2","unstructured":"Rank W.\u2010R. DiPauli R.andRank U. Vortragsreferate der l. Tagung der Gesellschaft fur Immunologie Freiburg1969 p.8."},{"key":"e_1_2_1_30_2","unstructured":"Rank W.\u2010R.andFl\u00fcgge\u2010Rank U. Vortragsreferate der 3. Tagung der Gesellschaft f\u00fcr Immunologie Marburg1971 p.93."},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/208859a0"},{"key":"e_1_2_1_32_2","first-page":"522","volume-title":"Bacterial Endotoxins","author":"Watson D. W.","year":"1964"},{"key":"e_1_2_1_33_2","first-page":"181","volume":"1","author":"Howard J. G.","year":"1958","journal-title":"Immunology"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103710"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.2.309"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1515\/znb-1958-0903","volume":"13","author":"Westphal O.","year":"1958","journal-title":"Z. Naturforsch."},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.118.3.425"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.121.5.751"},{"key":"e_1_2_1_39_2","first-page":"482","volume-title":"Bacterial Endotoxins","author":"Petersdorf R. G.","year":"1964"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/2241316a0"},{"key":"e_1_2_1_41_2","first-page":"104","volume-title":"The Biology of Animal Viruses","author":"Fenner F.","year":"1968"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01241850"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1961.tb00214.x"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.3.3.405"},{"key":"e_1_2_1_45_2","first-page":"529","volume":"36","author":"Crisler C.","year":"1966","journal-title":"J. Nat. Cancer Inst."},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/1821165a0"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830020610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830020610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T04:39:30Z","timestamp":1698899970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830020610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,12]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1972,12]]}},"alternative-id":["10.1002\/eji.1830020610"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830020610","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,12]]}}}