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This cross\u2010reactivity has been conclusively established on the cellular level, both <jats:italic>in vivo<\/jats:italic> by means of delayed hypersensitivity skin tests and <jats:italic>in vitro<\/jats:italic> using transformation of sensitized lymphocytes, as measured by incorporation of radioactive thymidine. The <jats:italic>in vitro<\/jats:italic> experiments have been conducted with lymph node cells from guinea pigs of both random bred and inbred strains, and on spleen and lymph node cells from rabbits. Definite cross\u2010reactivity was observed between the basic encephalitogen and all the synthetic copolymers which were previously shown effective in suppression of EAE, whereas ineffective copolymers or unrelated proteins did not show any cross\u2010reactivity. In the case of strain 2 guinea pigs and rabbit lymph node cells the cross\u2010reactivity <jats:italic>in vitro<\/jats:italic> was manifested by direct cross\u2010stimulation of the lymphocytes, whereas in random\u2010bred or strain 13 guinea pigs and rabbit spleen cells, the cross\u2010reaction was detected only by means of specific inhibition of the homologous stimulation by the heterologous antigen.<\/jats:p><jats:p>A limited extent of cross\u2010reactivity was observed on the humoral level as well; antibodies provoked in guinea pigs against the synthetic copolymer Cop 1 cross\u2010reacted in the passive cutaneous anaphylaxis assay with the bovine basic encephalitogen.<\/jats:p>","DOI":"10.1002\/eji.1830030506","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T23:06:56Z","timestamp":1172617616000},"page":"279-286","source":"Crossref","is-referenced-by-count":87,"title":["<i>In vivo and in vitro<\/i> immunological cross\u2010reactions between basic encephalitogen and synthetic basic polypeptides capable of suppressing experimental allergic encephalomyelitis"],"prefix":"10.1002","volume":"3","author":[{"given":"Cynthia","family":"Webb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dvora","family":"Teitelbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Arnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830010406"},{"key":"e_1_2_1_3_2","first-page":"656","volume":"8","author":"Webb C.","year":"1972","journal-title":"Isr. 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