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Treatment of spleen cells with anti\u2010immunoglobulin serum and complement, or removal of macrophages had little or no effect on cytotoxicity. Specific or nonspecific soluble cytotoxic factors were not detected, and exogenous interferon did not enhance cytotoxicity. No blocking of cytotoxicity was detected with either hyperimmune or 9\u2010day immune anti\u2010ectromelia serum. By varying the spleen cell\u2010target cell ratio from 3: 1 to 400: 1, it was shown that the efficiency of cytotoxicity was inversely related to spleen cell density. These results were interpreted to mean that thymus\u2010derived (T) cells, probably acting alone, were responsible for cytotoxicity and that the mechanism involved contact between T cell and target cell.<\/jats:p>","DOI":"10.1002\/eji.1830040203","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:07:01Z","timestamp":1172621221000},"page":"68-72","source":"Crossref","is-referenced-by-count":46,"title":["Cell\u2010mediated cytotoxicity against ectromelia virus\u2010infected target cells. II. Identification of effector cells and analysis of mechanisms"],"prefix":"10.1002","volume":"4","author":[{"given":"I.","family":"Gardner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narelle A.","family":"Bowern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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