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The detect in the ability of low responder mice to mount an immune response to this antigen appears to be expressed in their B cell population since the presence of thymocytes, or addition of \u201ceducated T cells\u201d or supernatant of T cells after stimulation with the antigen neither enhanced, nor suppressed the level of antibodies produced in both low and high responder mice. Low responsiveness could not be enhanced either by stimulation of macrophages or by injection of poly(A). poly(U) in contrast to the significant effect of these agents on low responses to the thymus\u2010dependent poly(<jats:sc>L<\/jats:sc>Tyr, <jats:sc>L<\/jats:sc>Glu)\u2010poly(<jats:sc>L<\/jats:sc>Pro)\u2010\u2010poly(<jats:sc>L<\/jats:sc>Lys) [<jats:sc>L<\/jats:sc>(T, G)\u2010Pro\u2010\u2010L]. These results suggest that macrophages do not participate in the limiting step, or are not involved at all, in anti\u2010body production towards the thymus\u2010independent polypeptide.<\/jats:p><jats:p>The antibodies produced in response to <jats:sc>D<\/jats:sc>(T, G)\u2010Pro\u2010\u2010L were found to be mainly of the 7 S class. T cells are not required for the production of mercaptoethanol resistant antibodies to this immunogen since they were found in intact mice as well as in T cell depleted animals.<\/jats:p>","DOI":"10.1002\/eji.1830050713","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T01:40:35Z","timestamp":1172626835000},"page":"496-501","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of the role of different cell types in the genetic regulation of antibody production to the thymus\u2010independent synthetic polypeptide poly (<scp>D<\/scp>Tyr, <scp>D<\/scp>Glu)\u2010poly(<scp>D<\/scp>Pro)\u2010\u2010poly (<scp>D<\/scp>Lys)"],"prefix":"10.1002","volume":"5","author":[{"given":"Anne\u2010Marie","family":"Schmitt\u2010Verhulst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna","family":"Mozes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01564074"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.9.2696"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.112.1.404","volume":"112","author":"Baker P. 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