{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:06:07Z","timestamp":1699459567900},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":11004,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1975,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By the aid of two alkylating agents (cyclophosphamide (CP) and 036.5122, (Asta), applied after a single dose of antigen, tolerance to sheep red blood cells (SRBC), has been induced in NMRI mice. Duration and characteristics of recovery were followed by a second antigenic challenge at various time intervals and by determination of 19 S and 7 S plaque\u2010forming cells (PFC) 4 days later. During recovery from the tolerant state two phases of responsiveness could be differentiated: an early phase with no or markedly reduced numbers of total PFC, all of them being of the IgM type; a later phase with a steady increase in total PFC up to normal values, paralleled by an increase in the proportion of 7 S PFC finally reaching 90% of total PFC. In comparison with CP, recovery from tolerance induced by equitoxic doses of 5122 were delayed and modified. Even after 8 weeks, total PFC to SRBC were still depressed, and the ratio 19 S\/7 S PFC resembled neither a typical primary nor secondary pattern.<\/jats:p><jats:p>It is concluded that CP\u2010mediated immunological tolerance is followed spontaneously by the establishment of a memory state. This observation, in agreement with findings of other authors, is interpreted as the expression of an established B cell memory compartment during the period of deficient T cell activity. The long\u2010lasting modification of specific responsiveness after 5122 indicates a profound disturbance of the potency to recover from the impact of this alkylating agent, the biological base of which is as yet unidentified.<\/jats:p><jats:p>It is suggested that observation of the characteristic features during the recovery phase from tolerance may help to clarify the nature of the defect in specific responsiveness.<\/jats:p>","DOI":"10.1002\/eji.1830051003","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T01:06:48Z","timestamp":1172624808000},"page":"667-671","source":"Crossref","is-referenced-by-count":4,"title":["Kinetics of the reactive cell clones after immunosuppression and induction of tolerance. II. Different recovery of 19 S and 7 S plaque\u2010forming cells after induction of tolerance"],"prefix":"10.1002","volume":"5","author":[{"given":"U.","family":"Botzenhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.\u2010M.","family":"Lemmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.125.5.833"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/213498a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.1.35"},{"key":"e_1_2_1_5_2","first-page":"909","volume":"30","author":"Dietrich F. M.","year":"1967","journal-title":"Pathol. 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G.","year":"1975","journal-title":"Progr. Allergy"},{"key":"e_1_2_1_15_2","first-page":"27","volume":"20","author":"Siskind G. W.","year":"1961","journal-title":"Fed. Proc."},{"key":"e_1_2_1_16_2","first-page":"896","volume":"29","author":"Mitchell M. S.","year":"1969","journal-title":"Cancer Res."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830010302"},{"key":"e_1_2_1_18_2","volume":"1595","author":"Botzenhardt U.","year":"1974","journal-title":"Verh. Dtsch. Ges. Inn. 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