{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:54:10Z","timestamp":1769280850192,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":10699,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1976,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The possibility that IgE is a secretory immunoglobulin has been examined by studying the tissue and cellular localization of IgE in rats infested with the enteric parasite, <jats:italic>Nippostrongylus brasiliensis.<\/jats:italic> The lamina propria of the small intestine and the colonic and pulmonary mucosal surfaces contained numerous anti\u2010IgE\u2010binding cells, but these were shown to be mast cells and not plasma cells. The major site of IgE synthesis was the regional lymph node of the small intestine, the mesenteric node, which contained large numbers of IgE\u2010secreting plasma cells. Smaller numbers of IgE\u2010secreting plasma cells were also found in the axillary node, which drained the site of larvae injection. Peyer's patches, the intrapulmonary bronchial lymphoid tissue and the spleen contained few, if any, IgE\u2010secreting plasma cells. The significance of the IgE which was readily demonstrated in germinal centers of the mesenteric lymph nodes, the Peyer's patches and the axillary lymph nodes, is not known. In contrast to the infested animals, the lymphoid organs of normal rats rarely contained any IgE\u2010containing cells. An unexpected observation was that mast cells in mucosal organs appear to contain intracellular IgE, differing in this respect from connective tissue mast cells. Mast cells lying between epithelial cells, the \u201cglobule leukocytes\u201d, also appear to contain intracellular IgE, and it is suggested that such cells may be responsible for the presence of IgE in exocrine secretions. This study does not support the suggestion that IgE is a secretory immunoglobulin with a Physiology analogous to that of IgA.<\/jats:p>","DOI":"10.1002\/eji.1830060803","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T04:19:27Z","timestamp":1172636367000},"page":"537-545","source":"Crossref","is-referenced-by-count":88,"title":["Nature of cells binding anti\u2010IgE in rats immunized with <i>Nippostrongylus brasiliensis<\/i>: IgE synthesis in regional nodes and concentration in mucosal mast cells"],"prefix":"10.1002","volume":"6","author":[{"given":"G.","family":"Mayrhofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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